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CITRUS RETICULATA PEEL OIL

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (high)

Cancer

Cancer concern is LOW_MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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facial moisturizer/treatment34 products
moisturizer24 products
moisturizer with SPF18 products
body wash/cleanser17 products
facial cleanser15 products
serums & essences15 products
shampoo12 products
beach & sport sunscreen12 products
mask11 products
lipstick9 products
liquid hand soap8 products
exfoliant/scrub7 products
hair styling aide6 products
antiperspirant/deodorant6 products
body oil5 products
conditioner5 products
vapor rubs5 products
hand cream4 products
hair treatment/serum4 products
toners/astringents4 products
lip balm3 products
body firming lotion3 products
baby oil3 products
bath oil/salts/soak3 products
fragrance for women2 products
hair spray2 products
BB cream2 products
baby bubble bath2 products
around-eye cream2 products
hand sanitizer2 products
anti-aging1 products
bubble bath1 products
baby lotion1 products
after sun product1 products
baby shampoo1 products
baby soap1 products
shaving cream (men's)1 products
antiperspirant/deodorant (men's)1 products
baby wipes1 products
eye shadow1 products
styling gel/lotion1 products
shaving cream1 products
body spray1 products
diaper cream1 products
cuticle treatment1 products
detangler1 products
makeup remover1 products
other men's products1 products

Allergies/immunotoxicity

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Concern Reference
The European Commission's Scientific Committee on Consumer Safety reports this substance is an established contact allergen in humans.EU Cosmetics Directive 2013. Opinion on Frangrance allergens in cosmetics (2011)
Fragrance chemical, which is less frequently reported and thus less documented as a consumer allergen.European Union 2015. Banned and Restricted Fragrances. Appears as: listid: EUFRAG-046; Chemical_Name: Limonene; Synonyms: d-Limonene;
Human [[system]] toxicant or allergen - strong evidenceEnvironmental Protection Agency (EPA) 2018. Safer Chemical Ingredients List (2018-02-28). Appears as: CAS: 5989-27-5; List Name: d-Limonene; TSCA Chemical Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-
May cause sensitization by skin contactEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
May cause sensitization by skin contact, with allergic reaction in skin or lungsUS. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
Limited evidence of [[system]] toxicity or allergiesEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Tangor, Murcote, ext.; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; -; citrus nobilis var. deliciosa swingle var. tangerine oil; Citrus reticulata; Essential oil of tangerines obtained from the peel o; cas_numbers: 93686-22-7

Irritation (skin, eyes, or lungs)

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Concern Reference
Irritant (eyes, skin, or lungs)EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
Restrictions recommended due to presence of photoirritating components.International Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-223; Chemical_Name: Citrus oils and other furocoumarins-containing essential oils; ; ; Classification: Restricted

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative toxicant - Oslo-Paris (OSPAR) Convention for the Protection of the Marine Environment of the North-East Atlantic, chemical of concernOSPAR Comission 2015. OSPAR PBTs - Substances of Possible Concern. Appears as: listid: PBT-OSPAR-249; Chemical_Name: (4R)-CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-; Synonyms: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; CAS: 5989-27-5
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as medium human health priorityEnvironment Canada Domestic Substance List
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Cancer

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Concern Reference
Restrictions recommended due to presence of phototumorigenic components.International Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-223; Chemical_Name: Citrus oils and other furocoumarins-containing essential oils; ; ; Classification: Restricted
IARC Group 3 (no cancer link)IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5

Developmental/reproductive toxicity

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Concern Reference
Developmental toxicity (significant increase in the number of fetuses with skeletal abnormalities, including lumbar ribs, fused ribs, and delayed ossification of several bones in the paws) were observed in the animals administered 2363 mg/kg/day.1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873.

Ecotoxicology

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Concern Reference
Dangerous for the environmentEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected aquatic toxicity.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Miscellaneous

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Concern Reference
FlammableEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5

Data gaps

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Concern Reference
16 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Use restrictions

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Concern Reference
Restricted in cosmetics - labeling requirement for allergensEU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5

Data Sources

  • EU Cosmetics Directive 2013. Opinion on Frangrance allergens in cosmetics (2011)
  • European Union 2015. Banned and Restricted Fragrances. Appears as: listid: EUFRAG-046; Chemical_Name: Limonene; Synonyms: d-Limonene;
  • Environmental Protection Agency (EPA) 2018. Safer Chemical Ingredients List (2018-02-28). Appears as: CAS: 5989-27-5; List Name: d-Limonene; TSCA Chemical Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-
  • EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
  • US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Tangor, Murcote, ext.; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; -; citrus nobilis var. deliciosa swingle var. tangerine oil; Citrus reticulata; Essential oil of tangerines obtained from the peel o; cas_numbers: 93686-22-7
  • International Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-223; Chemical_Name: Citrus oils and other furocoumarins-containing essential oils; ; ; Classification: Restricted
  • OSPAR Comission 2015. OSPAR PBTs - Substances of Possible Concern. Appears as: listid: PBT-OSPAR-249; Chemical_Name: (4R)-CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-; Synonyms: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; CAS: 5989-27-5
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
  • 1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5

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