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CITRUS RETICULATA PEEL OIL

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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facial moisturizer/treatment37 products
beach & sport sunscreen28 products
moisturizer with SPF26 products
moisturizer25 products
facial cleanser17 products
body wash/cleanser17 products
shampoo13 products
serums & essences13 products
mask11 products
body oil11 products
exfoliant/scrub9 products
lip balm8 products
liquid hand soap8 products
toners/astringents5 products
hair styling aide5 products
baby oil5 products
vapor rubs5 products
antiperspirant/deodorant4 products
conditioner4 products
fragrance for women4 products
hair treatment/serum4 products
bath oil/salts/soak3 products
hand cream3 products
around-eye cream2 products
baby bubble bath2 products
BB cream2 products
lip balm with SPF2 products
shaving cream (men's)2 products
hand sanitizer2 products
anti-aging1 products
after sun product1 products
body spray1 products
makeup remover1 products
body firming lotion1 products
baby shampoo1 products
bubble bath1 products
shaving cream1 products
hair spray1 products
makeup with SPF1 products
baby soap1 products
baby lotion1 products
diaper cream1 products
cuticle treatment1 products
antiperspirant/deodorant (men's)1 products
detangler1 products

Allergies/immunotoxicity

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Concern Reference
Known human any toxicant or allergenEU Cosmetics Directive 2013. Opinion on Frangrance allergens in cosmetics (2011)
Possible human any toxicant or allergenEuropean Union 2015. Banned and Restricted Fragrances. Appears as: listid: EUFRAG-046; Chemical_Name: Limonene; Synonyms: d-Limonene;
Human any toxicant or allergen - strong evidenceEnvironmental Protection Agency (EPA) 2018. Safer Chemical Ingredients List (2018-02-28). Appears as: CAS: 5989-27-5; List Name: d-Limonene; TSCA Chemical Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-
Limited evidence of any toxicity or allergiesEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
Limited evidence of any toxicity or allergiesUS. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
Limited evidence of any toxicity or allergiesEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Tangor, Murcote, ext.; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; -; citrus nobilis var. deliciosa swingle var. tangerine oil; Citrus reticulata; Essential oil of tangerines obtained from the peel o; cas_numbers: 93686-22-7

Irritation (skin, eyes, or lungs)

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Concern Reference
Classified as any irritantEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5

Use restrictions

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Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - anyCosIng
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - anyCosIng
Restricted in cosmetics - labeling requirement for allergensEU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeOSPAR Comission 2015. OSPAR PBTs - Substances of Possible Concern. Appears as: listid: PBT-OSPAR-249; Chemical_Name: (4R)-CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-; Synonyms: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; CAS: 5989-27-5
Not suspected to be persistentEnvironment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
Not suspected to be bioaccumulativeEnvironment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as medium human health priorityEnvironment Canada Domestic Substance List
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Developmental/reproductive toxicity

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Concern Reference
One or more animal studies show any effects at high doses1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873.

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
Suspected to be an environmental toxinEnvironment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Miscellaneous

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Concern Reference
Occupational hazards related to handlingEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5

Cancer

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Concern Reference
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gapsIARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5

Data gaps

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Concern Reference
16 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Data Sources

  • EU Cosmetics Directive 2013. Opinion on Frangrance allergens in cosmetics (2011)
  • European Union 2015. Banned and Restricted Fragrances. Appears as: listid: EUFRAG-046; Chemical_Name: Limonene; Synonyms: d-Limonene;
  • Environmental Protection Agency (EPA) 2018. Safer Chemical Ingredients List (2018-02-28). Appears as: CAS: 5989-27-5; List Name: d-Limonene; TSCA Chemical Name: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-
  • EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
  • US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Tangor, Murcote, ext.; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; -; citrus nobilis var. deliciosa swingle var. tangerine oil; Citrus reticulata; Essential oil of tangerines obtained from the peel o; cas_numbers: 93686-22-7
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5
  • OSPAR Comission 2015. OSPAR PBTs - Substances of Possible Concern. Appears as: listid: PBT-OSPAR-249; Chemical_Name: (4R)-CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-; Synonyms: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; CAS: 5989-27-5
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • 1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873.
  • IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer