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CI 15850 (D&C Red No. 6 or 7)

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Irritation (skin, eyes, or lungs) (low), and Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick1403 products
lip gloss305 products
lip liner238 products
eye liner169 products
blush128 products
eye shadow115 products
lip balm53 products
bronzer/highlighter42 products
foundation29 products
facial powder26 products
concealer23 products
lip balm with SPF17 products
glitter15 products
nail polish15 products
makeup primer9 products
hair color and bleaching8 products
7 products
exfoliant/scrub6 products
CC cream6 products
hair styling aide3 products
body wash/cleanser2 products
serums & essences1 products
lip plumper1 products
facial moisturizer/treatment1 products
hair spray1 products

Contamination concerns

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Use restrictions

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Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status

Cancer

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Concern Reference
Cancer - weight of evidence unknown/unassessedScientific Committee on Consumer Safety (SCCS) OPINION ON Pigment Red 57, COLIPA n° C181. October 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf

Irritation (skin, eyes, or lungs)

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Concern Reference
Caused mild skin irritation in animal tests.Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.

Allergies/immunotoxicity

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Concern Reference
May cause or exacerbate dermatitis.Gabsik Yang, Hye Eun Lee, Kyung-Min Lim, Yong-Kyu Choi, Kyu-Bong Kim, Byung-Mu Lee & Joo Young Lee 2018. Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms. Chemico-biological interactions 284, 41-47.

Data gaps

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Concern Reference
Considered safe based on assumption of low absorptionScientific Committee on Consumer Safety (SCCS) OPINION ON Pigment Red 57, COLIPA n° C181. October 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf
The European SCCS recommends that the safety of Pigment Red 57 should be assessed for hair dyes and other uses.Scientific Committee on Consumer Safety (SCCS) OPINION ON Pigment Red 57, COLIPA n° C181. October 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf
0 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
Classified as a low human health priorityEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • Scientific Committee on Consumer Safety (SCCS) OPINION ON Pigment Red 57, COLIPA n° C181. October 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf
  • Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
  • Gabsik Yang, Hye Eun Lee, Kyung-Min Lim, Yong-Kyu Choi, Kyu-Bong Kim, Byung-Mu Lee & Joo Young Lee 2018. Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms. Chemico-biological interactions 284, 41-47.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
  • Products with the EWG VERIFIED mark have met the program’s impurity and use restrictions based on EWG's review of the company's data.

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