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CI 15850 (D&C Red No. 6 or 7)
Score:
Data: Limited
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high), Irritation (skin, eyes, or lungs) (low), and Contamination concerns (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| lipstick | 1403 products |
| lip gloss | 305 products |
| lip liner | 238 products |
| eye liner | 169 products |
| blush | 128 products |
| eye shadow | 115 products |
| lip balm | 53 products |
| bronzer/highlighter | 42 products |
| foundation | 29 products |
| facial powder | 26 products |
| concealer | 23 products |
| lip balm with SPF | 17 products |
| glitter | 15 products |
| nail polish | 15 products |
| makeup primer | 9 products |
| hair color and bleaching | 8 products |
| 7 products | |
| exfoliant/scrub | 6 products |
| CC cream | 6 products |
| hair styling aide | 3 products |
| body wash/cleanser | 2 products |
| serums & essences | 1 products |
| lip plumper | 1 products |
| facial moisturizer/treatment | 1 products |
| hair spray | 1 products |
Contamination concerns
| Chemical |
|---|
| ANILINE |
| CADMIUM (pyrophoric) |
Use restrictions
| Concern | Reference |
|---|---|
| Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyes | FDA Color Additive Status |
Cancer
| Concern | Reference |
|---|---|
| Cancer - weight of evidence unknown/unassessed | Scientific Committee on Consumer Safety (SCCS) OPINION ON Pigment Red 57, COLIPA n° C181. October 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Caused mild skin irritation in animal tests. | Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf. |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| May cause or exacerbate dermatitis. | Gabsik Yang, Hye Eun Lee, Kyung-Min Lim, Yong-Kyu Choi, Kyu-Bong Kim, Byung-Mu Lee & Joo Young Lee 2018. Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms. Chemico-biological interactions 284, 41-47. |
Data gaps
| Concern | Reference |
|---|---|
| Considered safe based on assumption of low absorption | Scientific Committee on Consumer Safety (SCCS) OPINION ON Pigment Red 57, COLIPA n° C181. October 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf |
| The European SCCS recommends that the safety of Pigment Red 57 should be assessed for hair dyes and other uses. | Scientific Committee on Consumer Safety (SCCS) OPINION ON Pigment Red 57, COLIPA n° C181. October 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf |
| 0 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmetics | FDA Color Additive Status |
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug Administration | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
| Classified as a low human health priority | Environment Canada Domestic Substance List |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
- Scientific Committee on Consumer Safety (SCCS) OPINION ON Pigment Red 57, COLIPA n° C181. October 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf
- Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
- Gabsik Yang, Hye Eun Lee, Kyung-Min Lim, Yong-Kyu Choi, Kyu-Bong Kim, Byung-Mu Lee & Joo Young Lee 2018. Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms. Chemico-biological interactions 284, 41-47.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
- Products with the EWG VERIFIED mark have met the program’s impurity and use restrictions based on EWG's review of the company's data.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
ABOUT EWG VERIFIED™
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer
