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Acid Violet 43 (Uncertified Ext. D&C Violet No. 2)
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high), Non-reproductive organ system toxicity (moderate), Irritation (skin, eyes, or lungs) (low), and Contamination concerns (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| shampoo | 2 products |
| hair color and bleaching | 2 products |
| conditioner | 2 products |
| hair treatment/serum | 1 products |
Contamination concerns
Use restrictions
| Concern | Reference |
|---|---|
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | CTFA International Cosmetic Ingredient Dictionary and Handbook |
| Color additive not approved by FDA for cosmetics used around eyes | US. Food and Drug Administration (FDA). 2020. Color Additive Status. Appears as: ; Chemical_Name: ACID VIOLET 43; ; |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | IJT 20(S3):1-6, 2001 |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Human skin toxicant or allergen - strong evidence | EWG Assessment of Open Scientific Literature |
| Testing was inadequate to exclude the posibility for dermal sensitizaton. | European Commission, Scientific Committee on Consumer Safety (SCCS) 2013. Opinion on Acid Violet 43 COLIPA n° C63. |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Potential impacts on blood clotting observed in animal testing. | European Commission, Scientific Committee on Consumer Safety (SCCS) 2013. Opinion on Acid Violet 43 COLIPA n° C63. |
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Cancer
| Concern | Reference |
|---|---|
| Cancer - limited evidence | IJT 20(S3):1-6, 2001 |
| Cancer - limited evidence | EWG Assessment of Open Scientific Literature |
| Genotoxicity reprorted in vitro tests. | European Commission, Scientific Committee on Consumer Safety (SCCS) 2013. Opinion on Acid Violet 43 COLIPA n° C63. |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Causes serious eye damage. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Sodium 4-[(9,10-dihydro-4-hydroxy-9,10-dioxo-1-anthryl)amino]toluene-3-sulphonate; sodium 2-[(4-hydroxy-9,10-dioxo-9,10-dihydroanthracen-1-yl)amino]-5-methylbenzene-1-sulfonate; Acid Violet 43; Benzenesulfonic acid, 2-((9,10-dihydro-4-hydroxy-9,10-dio; cas_numbers: 4430-18-6 |
| Eye irritation reported from limited animal testing. | European Commission, Scientific Committee on Consumer Safety (SCCS) 2013. Opinion on Acid Violet 43 COLIPA n° C63. |
Data gaps
| Concern | Reference |
|---|---|
| 192 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any | IJT 20(S3):1-6, 2001; Final report 12/2016 available from CIR |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- US. Food and Drug Administration (FDA). 2020. Color Additive Status. Appears as: ; Chemical_Name: ACID VIOLET 43; ;
- IJT 20(S3):1-6, 2001
- EWG Assessment of Open Scientific Literature
- European Commission, Scientific Committee on Consumer Safety (SCCS) 2013. Opinion on Acid Violet 43 COLIPA n° C63.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Sodium 4-[(9,10-dihydro-4-hydroxy-9,10-dioxo-1-anthryl)amino]toluene-3-sulphonate; sodium 2-[(4-hydroxy-9,10-dioxo-9,10-dihydroanthracen-1-yl)amino]-5-methylbenzene-1-sulfonate; Acid Violet 43; Benzenesulfonic acid, 2-((9,10-dihydro-4-hydroxy-9,10-dio; cas_numbers: 4430-18-6
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- IJT 20(S3):1-6, 2001; Final report 12/2016 available from CIR
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