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Acid Orange 7 (Uncertified D&C Orange No. 4)

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Irritation (skin, eyes, or lungs) (low), and Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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hair color and bleaching2 products

Contamination concerns

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Use restrictions

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Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCTFA International Cosmetic Ingredient Dictionary and Handbook

Persistence and bioaccumulation

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Concern Reference
Persistent or bioaccumulative and moderate to high toxicity concern in humansEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as medium human health priorityEnvironment Canada Domestic Substance List
Causes damage to organs through prolonged or repeated exposureEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate; sodium 4-[(E)-2-(2-hydroxynaphthalen-1-yl)diazen-1-yl]benzene-1-sulfonate; -; Acid Orange 7; Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate; sodium 4-[(2-hydroxy-1-naphthyl)diazenyl]benzene; cas_numbers: 633-96-5
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

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Concern Reference
This substance is considered a mild skin irritant.European Commission, Scientific Committee on Consumer Safety (SCCS) 2014. Opinion on Acid Orange7 COLIPA n° C15.

Endocrine disruption

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Concern Reference
Evidence of endocrine activity from cellular assays.National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 633-96-5; Chemical_Name: Acid Orange II

Ecotoxicology

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Concern Reference
Harmful to aquatic life with long lasting effects.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate; sodium 4-[(E)-2-(2-hydroxynaphthalen-1-yl)diazen-1-yl]benzene-1-sulfonate; -; Acid Orange 7; Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate; sodium 4-[(2-hydroxy-1-naphthyl)diazenyl]benzene; cas_numbers: 633-96-5
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
396 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Color additive not approved by FDA for use in foodUS. Food and Drug Administration (FDA). 2020. Color Additive Status. Appears as: ; Chemical_Name: ACID ORANGE 7; ;

Data Sources

  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate; sodium 4-[(E)-2-(2-hydroxynaphthalen-1-yl)diazen-1-yl]benzene-1-sulfonate; -; Acid Orange 7; Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate; sodium 4-[(2-hydroxy-1-naphthyl)diazenyl]benzene; cas_numbers: 633-96-5
  • European Commission, Scientific Committee on Consumer Safety (SCCS) 2014. Opinion on Acid Orange7 COLIPA n° C15.
  • National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 633-96-5; Chemical_Name: Acid Orange II
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • US. Food and Drug Administration (FDA). 2020. Color Additive Status. Appears as: ; Chemical_Name: ACID ORANGE 7; ;

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