Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
|moisturizer with SPF||16 products|
|facial moisturizer/treatment||12 products|
|serums & essences||9 products|
|facial cleanser||8 products|
|beach & sport sunscreen||3 products|
|around-eye cream||2 products|
|liquid hand soap||2 products|
|makeup primer||2 products|
|makeup remover||2 products|
|hand cream||2 products|
|body wash/cleanser||1 products|
|sunless tanning||1 products|
|damaged skin treatment||1 products|
|foot cleansing||1 products|
|hair treatment/serum||1 products|
|hand sanitizer||1 products|
Multiple, additive exposure sources
|Used in food or as an additive with limited or no toxicity information available||FDA Everything Added to Food|
Irritation (skin, eyes, or lungs)
|Safe for use when formulated to be non-irritating||Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: BETAINE; ; CAS: 107-43-7; Classification: QQQ53; I;|
|CLP notification: this substance causes skin irritation||European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Betaine; 2-(trimethylazaniumyl)acetate; (Carboxymethyl)trimethylammonium inner salt, Oxyneurine, Trimethylglycine; (trimethylammonio)acetate; 2-(trimethylazaniumyl)acetate; Betaine; Betaine; BETAFIN®; BetaFrost®; GREENSTIM; NATURAL EXTRACT AP; NATUR; cas_numbers: 107-43-7|
|5710 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
|Not suspected to be an environmental toxin||Environment Canada Domestic Substance List|
Organ system toxicity (non-reproductive)
|Classified as not expected to be potentially toxic or harmful||Environment Canada Domestic Substance List|
Persistence and bioaccumulation
|Not suspected to be persistent||Environment Canada Domestic Substance List|
|Not suspected to be bioaccumulative||Environment Canada Domestic Substance List|
- FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
- Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: BETAINE; ; CAS: 107-43-7; Classification: QQQ53; I;
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Betaine; 2-(trimethylazaniumyl)acetate; (Carboxymethyl)trimethylammonium inner salt, Oxyneurine, Trimethylglycine; (trimethylammonio)acetate; 2-(trimethylazaniumyl)acetate; Betaine; Betaine; BETAFIN®; BetaFrost®; GREENSTIM; NATURAL EXTRACT AP; NATUR; cas_numbers: 107-43-7
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
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