EWG Skin Deep® | What is TROMETHAMINE

HOW WE DETERMINE SCORES Learn more About EWG VERIFIED®

Data: Fair

Tromethamine

Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

IMAGE SOURCE: PubChem

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Other Concerns

Use restrictions (moderate)

SYNONYMS

● 1,3-PROPANEDIOL, 2-AMINO-2-(HYDROXYMETHYL)-

● 1,3PROPANEDIOL, 2AMINO2(HYDROXYMETHYL)

● 2-AMINO-2-(HYDROXYMETHYL)- 1,3-PROPANEDIOL

● 2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL

● THAM

● TRIS(HYDROXYMETHYL)AMINO METHANE

● TRIS; TRIS, FREE BASE

● TROMETAMOL

● TROMETHAMINE

Restricted

Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation

Tromethamine is an aliphatic compound.

Common concerns

See how this product scores for common concerns.

LOW

Cancer
LOW

Allergies & Immunotoxicity
LOW

Developmental and Reproductive Toxicity
MODERATE

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

foundation	131 products
mask	126 products
facial moisturizer/treatment	101 products
serums & essences	46 products
around-eye cream	29 products
mascara	21 products
moisturizer	20 products
brow liner	18 products
toners/astringents	18 products
facial cleanser	17 products
makeup primer	11 products
exfoliant/scrub	9 products
eye liner	9 products
daily use with SPF	8 products
hand cream	6 products
hand sanitizer	6 products
anti-aging	5 products
blush	3 products
BB cream	3 products
concealer	2 products
hair treatment/serum	2 products
	2 products
foot moisturizer	2 products
foot cleansing	2 products
skin fading/lightener	2 products
foot odor control	2 products
body spray	1 products
setting powder/spray	1 products
baby lotion	1 products
tooth whitening	1 products
after sun product	1 products
cuticle treatment	1 products
bronzer/highlighter	1 products
facial cleansing wipes	1 products
makeup remover	1 products
recreational sunscreen	1 products
hair styling aide	1 products
body firming lotion	1 products
eye shadow	1 products

Use restrictions

CONCERN	REFERENCE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any	CosIng

Ecotoxicology

CONCERN	REFERENCE
Not suspected to be an environmental toxin	Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Classified as not expected to be potentially toxic or harmful	Environment Canada Domestic Substance List

Persistence and bioaccumulation

CONCERN	REFERENCE
Not suspected to be persistent	Environment Canada Domestic Substance List
Not suspected to be bioaccumulative	Environment Canada Domestic Substance List

Informational

CONCERN	REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any	Cosmetic Ingredient Review Assessments

Data gaps

CONCERN	REFERENCE
5873 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED^® mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST

Low Availability

Moderate Availability

High Availability