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TRICLOSAN

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate), Endocrine disruption (moderate), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), Irritation (skin, eyes, or lungs) (high), and Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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toothpaste1 products
facial cleanser1 products

Contamination concerns

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Chemical
CHLOROFORM
DIOXINS

Irritation (skin, eyes, or lungs)

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Concern Reference
Classified as irritantCPS&Q - Classification & Labelling

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeEmerging PBTs from peer-reviewed literature

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)Japan's Standards for Cosmetics

Endocrine disruption

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Concern Reference
One or more studies show endocrine disruption at very low dosesVeldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC, 2006 "The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development," Aquat Toxicol. 2006 Dec 1;80(3):217-27. Tata JR. "Amphibian metamorphosis as a model for studying the developmental actions of thyroid hormone." Ann Endocrinol (Paris). 1998;59(6):433-42.
One or more studies show moderate endocrine disruptionZorrilla LM, Gibson EK, Jeffay SC, et al 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences: an official journal of the Society of Toxicology 107(1), 56-64.

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as potentially toxic or harmfulCherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, et al 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proceedings of the National Academy of Sciences of the United States of America 109(35): 14158-14163.

Allergies/immunotoxicity

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Concern Reference
One or more human case studies show possible immune or allergenic effectsRees Clayton EM, Todd M, Beam Dowd J, Aiello AE 2011. The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006. Environmental Health Perspectives 119(3), 390-6.

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityCPS&Q - Classification & Labelling
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
1875 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
  • Emerging PBTs from peer-reviewed literature
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • Veldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC, 2006 "The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development," Aquat Toxicol. 2006 Dec 1;80(3):217-27. Tata JR. "Amphibian metamorphosis as a model for studying the developmental actions of thyroid hormone." Ann Endocrinol (Paris). 1998;59(6):433-42.
  • Zorrilla LM, Gibson EK, Jeffay SC, et al 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences: an official journal of the Society of Toxicology 107(1), 56-64.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, et al 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proceedings of the National Academy of Sciences of the United States of America 109(35): 14158-14163.
  • Rees Clayton EM, Todd M, Beam Dowd J, Aiello AE 2011. The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006. Environmental Health Perspectives 119(3), 390-6.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About this Ingredient's Score Range

  • Products with the EWG VERIFIED mark have met the program’s impurity and use restrictions based on EWG's review of the company's data.

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