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TRICLOCARBAN
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| antiperspirant/deodorant | 1 products |
Enhanced skin absorption
| Concern | Reference |
|---|---|
| About 7% of the triclocarban applied to the skin of 5 human test subjects penetrated the skin, as measured in urine. | Wester RC, Maibach HI, Surinchak J, Bucks DAW Predictability of in vitro diffusion systems: Effect of skin types and ages on percutaneous absorption of Triclocarban. Dermatol. 1985; 6:223-6. |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Persistent, bioaccumulative in wildlife | OSPAR PBTs - Substances of Possible Concern |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | CosIng |
| European Union Cosmetics Directive III/100: Rinse-off products, 1.5%; VI/23: As preservative, 0.2%. | European Union Cosmetics Directive |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as expected to be toxic or harmful | Environment Canada Domestic Substance List |
| Male rats exposed to 75 mg/kg/day triclocarban developed anemia and had increased spleen and liver weights. | Monsanto A twenty-four month dietary toxicity/carcinogenicity study of Triclocarban in rats. 1981. Report no. BDN-77-280. |
Developmental/reproductive toxicity
| Concern | Reference |
|---|---|
| All male sex accessory organs increased significantly in size in castrated, testosterone-treated male rats fed 0.25% triclocarban. | Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology. 2008 Mar;149(3):1173-9. |
Ecotoxicology
| Concern | Reference |
|---|---|
| Suspected to be an environmental toxin and be persistent or bioaccumulative | Environment Canada Domestic Substance List |
| Suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Endocrine disruption
| Concern | Reference |
|---|---|
| Triclocarban enhances the effects of testosterone, according to a study of castrated male rats. | Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology. 2008 Mar;149(3):1173-9. |
Data gaps
| Concern | Reference |
|---|---|
| 3752 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Data Sources
- Wester RC, Maibach HI, Surinchak J, Bucks DAW Predictability of in vitro diffusion systems: Effect of skin types and ages on percutaneous absorption of Triclocarban. Dermatol. 1985; 6:223-6.
- OSPAR (Oslo-Paris). 2002. OSPAR List of Substances of Possible Concern. Secondary OSPAR List of Substances of Possible Concern. Secondary OSPAR. Place Published, OSPAR Convention for the Protection of the Marine Environement of North-East Atlanic.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- European Union Cosmetics Directive
- Monsanto A twenty-four month dietary toxicity/carcinogenicity study of Triclocarban in rats. 1981. Report no. BDN-77-280.
- Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology. 2008 Mar;149(3):1173-9.
- Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology. 2008 Mar;149(3):1173-9.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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