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TOLUENE-2,5-DIAMINE SULFATE
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high), Ecotoxicology (low), and Occupational hazards (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| hair color and bleaching | 25 products |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| European SCCS: Toluene-2,5-diamine and its sulfate are extreme skin sensitizers. | Scientific Committee on Consumer Safety (SCCS), OPINION ON Toluene-2,5-diamine and its sulfate, COLIPA n A5 June 2012. |
| Human skin toxicant or allergen - strong evidence | Cosmetic Ingredient Review Assessments |
| Limited evidence of immune system toxicity or allergies | CPS&Q - Classification & Labelling |
Use restrictions
| Concern | Reference |
|---|---|
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | CosIng |
| Banned in Canadian cosmetics used around the eyes. | Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2011. |
| Determined safe for use in cosmetics, subject to concentration or use limitations - any | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Occupational hazards
| Concern | Reference |
|---|---|
| Allowed workplace exposures restricted to low doses | CPS&Q - Classification & Labelling |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as toxic or harmful | CPS&Q - Classification & Labelling |
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Cancer
| Concern | Reference |
|---|---|
| Cancer - limited evidence | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Ecotoxicology
| Concern | Reference |
|---|---|
| Wildlife and environmental toxicity | CPS&Q - Classification & Labelling |
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern | Reference |
|---|---|
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments |
| Insufficient data to determine safety | Final Report 3/04 Available from CIR |
| 37 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any | Cosmetic Ingredient Review Assessments |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- Scientific Committee on Consumer Safety (SCCS), OPINION ON Toluene-2,5-diamine and its sulfate, COLIPA n A5 June 2012.
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2011.
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- Final Report 3/04 Available from CIR
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- This ingredient’s score is higher if used in products intended for use around mouth due to increased risk of ingestion and absorption.
- This ingredient’s score is higher if used in products intended for use on lips due to increased risk of ingestion and absorption.
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