TOLUENE-2,5-DIAMINE SULFATE
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high), Ecotoxicology (low), and Occupational hazards (high)
Cancer 

Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity 

Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity 

Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
hair color and bleaching | 32 products |
Allergies/immunotoxicity
Concern | Reference |
---|---|
European SCCS: Toluene-2,5-diamine and its sulfate are extreme skin sensitizers. | Scientific Committee on Consumer Safety (SCCS), OPINION ON Toluene-2,5-diamine and its sulfate, COLIPA n A5 June 2012. |
Human skin toxicant or allergen - strong evidence | Cosmetic Ingredient Review Assessments |
Limited evidence of immune system toxicity or allergies | CPS&Q - Classification & Labelling |
Use restrictions
Concern | Reference |
---|---|
Violation of government restrictions - Banned or found unsafe for use in cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | CosIng |
Banned in Canadian cosmetics used around the eyes. | Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2011. |
Determined safe for use in cosmetics, subject to concentration or use limitations - any | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Occupational hazards
Concern | Reference |
---|---|
Allowed workplace exposures restricted to low doses | CPS&Q - Classification & Labelling |
Organ system toxicity (non-reproductive)
Concern | Reference |
---|---|
Classified as toxic or harmful | CPS&Q - Classification & Labelling |
Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Cancer
Concern | Reference |
---|---|
Cancer - limited evidence | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Ecotoxicology
Concern | Reference |
---|---|
Wildlife and environmental toxicity | CPS&Q - Classification & Labelling |
Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
Concern | Reference |
---|---|
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments |
Insufficient data to determine safety | Final Report 3/04 Available from CIR |
37 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Informational
Concern | Reference |
---|---|
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any | Cosmetic Ingredient Review Assessments |
Persistence and bioaccumulation
Concern | Reference |
---|---|
Not suspected to be persistent | Environment Canada Domestic Substance List |
Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- Scientific Committee on Consumer Safety (SCCS), OPINION ON Toluene-2,5-diamine and its sulfate, COLIPA n A5 June 2012.
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2011.
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- Final Report 3/04 Available from CIR
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- This ingredient’s score is higher if used in products intended for use around mouth due to increased risk of ingestion and absorption.
- This ingredient’s score is higher if used in products intended for use on lips due to increased risk of ingestion and absorption.
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