Other Concerns
Use restrictions (high), Ecotoxicology (low), and Occupational hazards (high)SYNONYMS
Unacceptable
Unacceptable: EWG VERIFIED products cannot contain this ingredient
Toluene-2, 5-Diamine is a substituted aromatic amine.
Common concerns
See how this product scores for common concerns.
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MODERATECancer
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HIGHAllergies & Immunotoxicity
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LOWDevelopmental and Reproductive Toxicity
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HIGHUse Restrictions
Ingredient concerns
- CONCERNS
- DATA SOURCES
Products with this Ingredient
hair color and bleaching | 17 products |
Allergies/immunotoxicity
CONCERN | REFERENCE |
---|---|
Known human any toxicant or allergen | Open scientific literature |
Possible human any toxicant or allergen | Open scientific literature |
Human skin toxicant or allergen - strong evidence | Cosmetic Ingredient Review Assessments |
Limited evidence of immune system toxicity or allergies | CPS&Q - Classification & Labelling |
Limited evidence of immune system toxicity or allergies | Scorecard.org Toxicity Information |
Limited evidence of immune system toxicity or allergies | National Library of Medicine HazMap |
Use restrictions
CONCERN | REFERENCE |
---|---|
Violation of government restrictions - Banned or found unsafe for use in cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - any | Open scientific literature |
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | CosIng |
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | Open scientific literature |
Determined safe for use in cosmetics, subject to concentration or use limitations - any | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Occupational hazards
CONCERN | REFERENCE |
---|---|
Allowed workplace exposures restricted to low doses | CPS&Q - Classification & Labelling |
Cancer
CONCERN | REFERENCE |
---|---|
Limited evidence of carcinogenicity | Open scientific literature |
Cancer - limited evidence | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gaps | Int'l Agency for Research on Cancer (IARC) - Carcinogens |
Not likely to be carcinogenic in humans | Open scientific literature |
Not likely to be carcinogenic in humans | Open scientific literature |
Organ system toxicity (non-reproductive)
CONCERN | REFERENCE |
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Classified as toxic or harmful | CPS&Q - Classification & Labelling |
Ecotoxicology
CONCERN | REFERENCE |
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Wildlife and environmental toxicity | CPS&Q - Classification & Labelling |
Data gaps
CONCERN | REFERENCE |
---|---|
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments |
Insufficient data to determine safety | Cosmetic Ingredient Review Assessments |
72 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Informational
CONCERN | REFERENCE |
---|---|
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any | Cosmetic Ingredient Review Assessments |
- Open scientific/peer reviewed literature
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
- ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Understanding scores
Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.
Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.
HOW WE DETERMINE SCORESHazard score
The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.
Data availability
The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.