EWG Skin Deep® | What is TOLUENE

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Data: Robust

Toluene

IMAGE SOURCE: PubChem

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Other Concerns

Use restrictions (high), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (high), Ecotoxicology (low), Irritation (skin, eyes, or lungs) (high), and Contamination concerns (high)

SYNONYMS

● BENZENE, METHYL

● BENZENE, METHYL-

● METHYL- BENZENE

● METHYLBENZENE

● TOLUENE

● TOLUOL

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient

A volatile petrochemical solvent and paint thinner, toluene is a potent neurotoxicant that acts as an irritant, impairs breathing, and causes nausea. Mother’s exposure to toluene vapors during pregnancy may cause developmental damage in the fetus. In human epidemiological studies and in animal studies toluene has been also associated with toxicity to the immune system and a possible link to blood cancer such as malignant lymphoma.

Common concerns

See how this product scores for common concerns.

LOW

Cancer
MODERATE

Allergies & Immunotoxicity
MODERATE

Developmental and Reproductive Toxicity
HIGH

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

nail polish	3 products
nail treatment	1 products

Contamination concerns

Chemical
BENZENE

Use restrictions

CONCERN	REFERENCE
Violation of industry recommendations - Unsafe for use in cosmetics	International Fragrance Association Codes & Standards
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any	CosIng
Determined safe for use in cosmetics, subject to concentration or use limitations - Restrictions on impurities recommended by industry safety panel	Cosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Known human respiratory toxicant	EPA Hazardous Air Pollutants
Classified as expected to be toxic or harmful	Environment Canada Domestic Substance List
Limited evidence of kidney toxicity	Scorecard.org Toxicity Information
Limited evidence of gastrointestinal or liver toxicity	National Library of Medicine HazMap
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)	EPA Toxic Release Inventory PBTs
One or more animal studies show any effects at moderate doses (low dose studies may be unavailable for this ingredient)	EPA Categorized List of Inert Pesticide Ingredients
Classified as a low human health priority	Environment Canada Domestic Substance List
reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox study	National Library of Medicine HazMap

Irritation (skin, eyes, or lungs)

CONCERN	REFERENCE
Classified as skin irritant	CPS&Q - Classification & Labelling
Human any irritant - strong evidence	Cosmetic Ingredient Review Assessments

Occupational hazards

CONCERN	REFERENCE
Allowed workplace exposures restricted to low doses	CPS&Q - Classification & Labelling
Allowed workplace exposures restricted to moderate doses	CPS&Q - Classification & Labelling

Developmental/reproductive toxicity

CONCERN	REFERENCE
Possible human developmental toxicant	California EPA Proposition 65
Human developmental toxicant - strong evidence	Scorecard.org Toxicity Information
Limited evidence of reproductive toxicity	National Library of Medicine HazMap
Limited evidence of reproductive toxicity	Scorecard.org Toxicity Information

Persistence and bioaccumulation

CONCERN	REFERENCE
Persistent or bioaccumulative and moderate to high toxicity concern in humans	Environment Canada Domestic Substance List
Not suspected to be bioaccumulative	Environment Canada Domestic Substance List

Allergies/immunotoxicity

CONCERN	REFERENCE
Limited evidence of immune system toxicity or allergies	Scorecard.org Toxicity Information

Ecotoxicology

CONCERN	REFERENCE
Wildlife and environmental toxicity	EPA Clean Water Act - Priority Pollutants
Suspected to be an environmental toxin and be persistent or bioaccumulative	Environment Canada Domestic Substance List
Suspected to be an environmental toxin	Environment Canada Domestic Substance List

Data gaps

CONCERN	REFERENCE
Considered safe based on assumption of low absorption	Cosmetic Ingredient Review Assessments
Insufficient data to determine safety	EPA Integrated Risk Information System (IRIS)
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product	Cosmetic Ingredient Review Assessments
17631 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

Miscellaneous

CONCERN	REFERENCE
Occupational hazards related to handling	CPS&Q - Classification & Labelling

Cancer

CONCERN	REFERENCE
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gaps	EPA Integrated Risk Information System (IRIS)
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gaps	Int'l Agency for Research on Cancer (IARC) - Carcinogens

Neurotoxicity

CONCERN	REFERENCE
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study	National Library of Medicine HazMap

Informational

CONCERN	REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any	Cosmetic Ingredient Review Assessments

IFRA (International Fragrance Association). 2006. Codes and Standards.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED^® mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST

Low Availability

Moderate Availability

High Availability