Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
|nail polish||5 products|
|Violation of industry recommendations - Unsafe for use in cosmetics||International Fragrance Association Codes & Standards|
|Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any||CosIng|
|Determined safe for use in cosmetics, subject to concentration or use limitations - Restrictions on impurities recommended by industry safety panel||Cosmetic Ingredient Review Assessments|
Organ system toxicity (non-reproductive)
|Known human respiratory toxicant||EPA Hazardous Air Pollutants|
|Classified as expected to be toxic or harmful||Environment Canada Domestic Substance List|
|Limited evidence of kidney toxicity||Scorecard.org Toxicity Information|
|Limited evidence of gastrointestinal or liver toxicity||National Library of Medicine HazMap|
|One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)||EPA Toxic Release Inventory PBTs|
|One or more animal studies show any effects at moderate doses (low dose studies may be unavailable for this ingredient)||EPA Categorized List of Inert Pesticide Ingredients|
|Classified as a low human health priority||Environment Canada Domestic Substance List|
|reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox study||National Library of Medicine HazMap|
Irritation (skin, eyes, or lungs)
|Classified as skin irritant||CPS&Q - Classification & Labelling|
|Human any irritant - strong evidence||Cosmetic Ingredient Review Assessments|
|Allowed workplace exposures restricted to low doses||CPS&Q - Classification & Labelling|
|Allowed workplace exposures restricted to moderate doses||CPS&Q - Classification & Labelling|
|Possible human developmental toxicant||California EPA Proposition 65|
|Human developmental toxicant - strong evidence||Scorecard.org Toxicity Information|
|Limited evidence of reproductive toxicity||National Library of Medicine HazMap|
|Limited evidence of reproductive toxicity||Scorecard.org Toxicity Information|
Persistence and bioaccumulation
|Persistent or bioaccumulative and moderate to high toxicity concern in humans||Environment Canada Domestic Substance List|
|Not suspected to be bioaccumulative||Environment Canada Domestic Substance List|
|Limited evidence of immune system toxicity or allergies||Scorecard.org Toxicity Information|
|Wildlife and environmental toxicity||EPA Clean Water Act - Priority Pollutants|
|Suspected to be an environmental toxin and be persistent or bioaccumulative||Environment Canada Domestic Substance List|
|Suspected to be an environmental toxin||Environment Canada Domestic Substance List|
|Considered safe based on assumption of low absorption||Cosmetic Ingredient Review Assessments|
|Insufficient data to determine safety||EPA Integrated Risk Information System (IRIS)|
|Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product||Cosmetic Ingredient Review Assessments|
|17631 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
|Occupational hazards related to handling||CPS&Q - Classification & Labelling|
|Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gaps||EPA Integrated Risk Information System (IRIS)|
|Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gaps||Int'l Agency for Research on Cancer (IARC) - Carcinogens|
|nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study||National Library of Medicine HazMap|
|Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any||Cosmetic Ingredient Review Assessments|
- IFRA (International Fragrance Association). 2006. Codes and Standards.
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
- EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
- CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
- California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
- EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
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