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TOCOPHERYL ACETATE
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
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Contamination concerns (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| lipstick | 1243 products |
| foundation | 507 products |
| concealer | 403 products |
| beach & sport sunscreen | 265 products |
| eye shadow | 249 products |
| moisturizer with SPF | 235 products |
| lip gloss | 227 products |
| moisturizer | 226 products |
| blush | 197 products |
| conditioner | 176 products |
| bronzer/highlighter | 173 products |
| facial moisturizer/treatment | 172 products |
| serums & essences | 146 products |
| shampoo | 121 products |
| mask | 120 products |
| body wash/cleanser | 102 products |
| brow liner | 98 products |
| liquid hand soap | 80 products |
| lip balm | 76 products |
| eye liner | 73 products |
| mascara | 71 products |
| facial powder | 70 products |
| facial cleanser | 63 products |
| around-eye cream | 55 products |
| hair treatment/serum | 54 products |
| makeup primer | 50 products |
| lip balm with SPF | 48 products |
| bath oil/salts/soak | 46 products |
| makeup remover | 45 products |
| lip liner | 42 products |
| exfoliant/scrub | 42 products |
| BB cream | 37 products |
| body firming lotion | 36 products |
| hand cream | 34 products |
| shaving cream | 32 products |
| hand sanitizer | 30 products |
| CC cream | 27 products |
| anti-aging | 26 products |
| baby wipes | 25 products |
| antiperspirant/deodorant | 25 products |
| hair styling aide | 25 products |
| body oil | 20 products |
| after sun product | 15 products |
| bubble bath | 14 products |
| beard oil | 14 products |
| hair color and bleaching | 13 products |
| styling gel/lotion | 13 products |
| shaving cream (men's) | 12 products |
| baby lotion | 12 products |
| sunless tanning | 12 products |
| toners/astringents | 12 products |
| baby sunscreen | 12 products |
| polish remover | 11 products |
| body spray | 11 products |
| bar soap | 11 products |
| diaper cream | 11 products |
| foot moisturizer | 10 products |
| other eye makeup | 9 products |
| hair spray | 9 products |
| lip plumper | 9 products |
| baby shampoo | 8 products |
| fragrance for women | 8 products |
| antiperspirant/deodorant (men's) | 8 products |
| after shave | 8 products |
| nail treatment | 6 products |
| baby soap | 6 products |
| oil controller | 5 products |
| toothpaste | 5 products |
| 5 products | |
| beard care | 5 products |
| damaged skin treatment | 4 products |
| fragrance for men | 4 products |
| detangler | 4 products |
| makeup with SPF | 3 products |
| depilatory | 2 products |
| cuticle treatment | 2 products |
| eye makeup remover | 2 products |
| baby powder | 2 products |
| baby oil | 2 products |
| nail polish | 2 products |
| styling mousse/foam | 2 products |
| foot cleansing | 2 products |
| hair relaxer | 2 products |
| tanning oil | 1 products |
| muscle/joint soreness | 1 products |
| foot odor control | 1 products |
| eyelash glue | 1 products |
| baby bubble bath | 1 products |
| glitter | 1 products |
Contamination concerns
| Chemical |
|---|
| HYDROQUINONE |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Human skin toxicant or allergen - strong evidence | Cosmetic Ingredient Review Assessments |
Cancer
| Concern | Reference |
|---|---|
| tocopheryl acetate enhanced photocarcinogenesis in an animal study | Gensler HL, Aickin M, Peng YM, Xu M 1996. Importance of the form of topical vitamin E for prevention of photocarcinogenesis. Nutr Cancer 26(2): 183-91. |
Ecotoxicology
| Concern | Reference |
|---|---|
| Suspected to be an environmental toxin and be persistent or bioaccumulative (uncertainty in environmental toxicity or persistence/bioaccumulation) | Environment Canada Domestic Substance List |
| Uncertain environmental toxin and uncertain persistent or bioaccumulative | Environment Canada Domestic Substance List |
Data gaps
| Concern | Reference |
|---|---|
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments |
| 5742 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Multiple, additive exposure sources
| Concern | Reference |
|---|---|
| Designated as safe for general or specific, limited use in food | FDA Food Additive Status |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any | Cosmetic Ingredient Review Assessments |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
| Classified as a low human health priority | Environment Canada Domestic Substance List |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- Gensler HL, Aickin M, Peng YM, Xu M 1996. Importance of the form of topical vitamin E for prevention of photocarcinogenesis. Nutr Cancer 26(2): 183-91.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
- FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
- Products with the EWG VERIFIED mark have met the program’s impurity restrictions based on EWG review of company data.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
ABOUT EWG VERIFIED™
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer
