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TOCOPHEROL

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick1002 products
foundation968 products
facial moisturizer/treatment503 products
moisturizer472 products
concealer392 products
beach & sport sunscreen387 products
lip balm366 products
lip gloss330 products
serums & essences282 products
eye shadow240 products
bronzer/highlighter217 products
eye liner212 products
moisturizer with SPF206 products
brow liner194 products
conditioner170 products
mask166 products
exfoliant/scrub161 products
lip liner154 products
facial cleanser148 products
shampoo145 products
blush136 products
body oil129 products
body wash/cleanser112 products
mascara110 products
around-eye cream98 products
antiperspirant/deodorant94 products
hair treatment/serum90 products
makeup primer81 products
hand cream69 products
lip balm with SPF61 products
facial powder56 products
liquid hand soap55 products
hair color and bleaching51 products
hair styling aide50 products
anti-aging47 products
bath oil/salts/soak44 products
baby lotion44 products
bar soap44 products
baby sunscreen41 products
body firming lotion40 products
makeup remover35 products
styling gel/lotion32 products
beard oil32 products
lip plumper32 products
CC cream28 products
fragrance for women27 products
toners/astringents25 products
BB cream24 products
diaper cream24 products
shaving cream24 products
23 products
baby soap22 products
baby oil20 products
sunless tanning19 products
hair spray15 products
foot moisturizer15 products
other eye makeup14 products
shaving cream (men's)13 products
baby wipes12 products
toothpaste12 products
baby shampoo12 products
fragrance for men12 products
antiperspirant/deodorant (men's)11 products
makeup with SPF10 products
after shave10 products
vapor rubs9 products
beard care9 products
cuticle treatment9 products
hand sanitizer9 products
detangler8 products
bubble bath8 products
eye makeup remover7 products
beard cleanser6 products
nail treatment6 products
muscle/joint soreness5 products
oil controller5 products
mouthwash4 products
after sun product4 products
body spray4 products
styling mousse/foam4 products
glitter4 products
damaged skin treatment3 products
other men's products3 products
depilatory3 products
baby powder2 products
foot odor control2 products
baby bubble bath2 products
skin fading/lightener2 products
foot cleansing2 products
tooth whitening1 products
tanning oil1 products
nail polish1 products
eyelash glue1 products
body art1 products
polish remover1 products

Contamination concerns

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Chemical
HYDROQUINONE

Cancer

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Concern Reference
Subcutaneously injection of Vitamin E induced formation of fast growing fibrosarcomata at the site of the injectionConstantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
43489 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Constantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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