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Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Contamination concerns (high)


Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick882 products
foundation719 products
moisturizer441 products
facial moisturizer/treatment436 products
beach & sport sunscreen390 products
concealer351 products
lip balm318 products
lip gloss271 products
serums & essences238 products
moisturizer with SPF206 products
bronzer/highlighter187 products
eye shadow172 products
eye liner142 products
conditioner140 products
exfoliant/scrub138 products
mask138 products
lip liner135 products
shampoo129 products
facial cleanser126 products
brow liner119 products
body oil109 products
blush109 products
body wash/cleanser104 products
antiperspirant/deodorant85 products
mascara79 products
around-eye cream79 products
hair treatment/serum66 products
lip balm with SPF61 products
makeup primer61 products
hand cream56 products
facial powder50 products
liquid hand soap46 products
anti-aging42 products
bath oil/salts/soak42 products
baby sunscreen41 products
hair color and bleaching41 products
hair styling aide35 products
baby lotion35 products
makeup remover33 products
body firming lotion32 products
bar soap30 products
fragrance for women27 products
CC cream27 products
styling gel/lotion25 products
BB cream25 products
shaving cream21 products
toners/astringents20 products
baby soap19 products
beard oil19 products
baby oil18 products
diaper cream16 products
hair spray15 products
sunless tanning14 products
other eye makeup13 products
fragrance for men12 products
toothpaste12 products
foot moisturizer11 products
lip plumper11 products
baby wipes10 products
baby shampoo10 products
vapor rubs9 products
hand sanitizer9 products
bubble bath9 products
after shave8 products
shaving cream (men's)8 products
eye makeup remover7 products
body spray7 products
detangler7 products
cuticle treatment7 products
antiperspirant/deodorant (men's)6 products
makeup with SPF5 products
after sun product4 products
nail treatment4 products
styling mousse/foam4 products
mouthwash4 products
oil controller4 products
glitter4 products
4 products
beard care3 products
muscle/joint soreness3 products
depilatory3 products
other men's products3 products
baby bubble bath2 products
baby powder2 products
foot odor control2 products
damaged skin treatment2 products
skin fading/lightener1 products
tanning oil1 products
foot cleansing1 products
tooth whitening1 products
body art1 products
polish remover1 products
eyelash glue1 products

Contamination concerns

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Concern Reference
Subcutaneously injection of Vitamin E induced formation of fast growing fibrosarcomata at the site of the injectionConstantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
43489 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed


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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food


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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Constantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.


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