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TOCOPHEROL

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick836 products
foundation573 products
facial moisturizer/treatment412 products
moisturizer399 products
beach & sport sunscreen394 products
concealer321 products
lip balm304 products
lip gloss261 products
serums & essences227 products
moisturizer with SPF206 products
bronzer/highlighter175 products
eye shadow171 products
exfoliant/scrub133 products
conditioner129 products
eye liner128 products
mask126 products
lip liner126 products
shampoo121 products
facial cleanser121 products
brow liner109 products
blush106 products
body oil96 products
body wash/cleanser92 products
antiperspirant/deodorant83 products
around-eye cream78 products
mascara76 products
hair treatment/serum61 products
lip balm with SPF60 products
makeup primer60 products
hand cream54 products
facial powder51 products
anti-aging43 products
hair color and bleaching41 products
baby sunscreen41 products
bath oil/salts/soak40 products
liquid hand soap39 products
baby lotion35 products
makeup remover32 products
hair styling aide32 products
body firming lotion31 products
bar soap30 products
CC cream27 products
styling gel/lotion25 products
fragrance for women24 products
BB cream23 products
shaving cream21 products
toners/astringents20 products
beard oil19 products
baby oil18 products
baby soap18 products
diaper cream15 products
other eye makeup13 products
sunless tanning13 products
hair spray12 products
toothpaste12 products
foot moisturizer11 products
fragrance for men11 products
lip plumper10 products
baby wipes10 products
baby shampoo10 products
after shave9 products
vapor rubs9 products
shaving cream (men's)8 products
bubble bath8 products
eye makeup remover7 products
detangler7 products
cuticle treatment7 products
hand sanitizer7 products
body spray7 products
makeup with SPF5 products
antiperspirant/deodorant (men's)5 products
styling mousse/foam4 products
glitter4 products
nail treatment4 products
after sun product4 products
oil controller4 products
mouthwash4 products
muscle/joint soreness3 products
other men's products3 products
beard care3 products
depilatory3 products
baby powder2 products
foot odor control2 products
damaged skin treatment2 products
baby bubble bath2 products
tanning oil1 products
skin fading/lightener1 products
tooth whitening1 products
eyelash glue1 products
body art1 products
polish remover1 products

Contamination concerns

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Chemical
HYDROQUINONE

Cancer

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Concern Reference
Subcutaneously injection of Vitamin E induced formation of fast growing fibrosarcomata at the site of the injectionConstantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
43489 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Constantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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