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TOCOPHEROL

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick897 products
foundation815 products
facial moisturizer/treatment456 products
moisturizer447 products
beach & sport sunscreen390 products
concealer362 products
lip balm333 products
lip gloss286 products
serums & essences252 products
moisturizer with SPF206 products
bronzer/highlighter199 products
eye shadow183 products
eye liner166 products
exfoliant/scrub148 products
conditioner147 products
mask142 products
lip liner140 products
brow liner139 products
shampoo134 products
facial cleanser128 products
body oil121 products
blush115 products
body wash/cleanser106 products
mascara94 products
antiperspirant/deodorant87 products
around-eye cream85 products
hair treatment/serum76 products
makeup primer67 products
lip balm with SPF61 products
hand cream58 products
facial powder51 products
liquid hand soap51 products
hair color and bleaching47 products
bath oil/salts/soak42 products
baby sunscreen41 products
hair styling aide40 products
anti-aging40 products
body firming lotion37 products
baby lotion36 products
makeup remover33 products
bar soap32 products
beard oil31 products
styling gel/lotion29 products
fragrance for women27 products
CC cream27 products
BB cream24 products
shaving cream22 products
toners/astringents22 products
baby soap19 products
baby oil18 products
diaper cream17 products
lip plumper17 products
sunless tanning15 products
hair spray15 products
other eye makeup14 products
foot moisturizer14 products
fragrance for men12 products
toothpaste12 products
12 products
baby wipes10 products
baby shampoo10 products
vapor rubs9 products
shaving cream (men's)9 products
hand sanitizer9 products
bubble bath9 products
beard care8 products
cuticle treatment8 products
makeup with SPF8 products
after shave8 products
antiperspirant/deodorant (men's)8 products
eye makeup remover7 products
body spray7 products
detangler7 products
muscle/joint soreness5 products
nail treatment5 products
after sun product5 products
styling mousse/foam4 products
mouthwash4 products
oil controller4 products
depilatory4 products
glitter4 products
other men's products3 products
beard cleanser3 products
baby bubble bath2 products
baby powder2 products
foot odor control2 products
damaged skin treatment2 products
skin fading/lightener1 products
tanning oil1 products
foot cleansing1 products
tooth whitening1 products
polish remover1 products
nail polish1 products
eyelash glue1 products
body art1 products

Contamination concerns

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Chemical
HYDROQUINONE

Cancer

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Concern Reference
Subcutaneously injection of Vitamin E induced formation of fast growing fibrosarcomata at the site of the injectionConstantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
43489 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Constantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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