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TOCOPHEROL

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick1034 products
foundation1031 products
facial moisturizer/treatment557 products
moisturizer518 products
lip balm444 products
beach & sport sunscreen441 products
concealer432 products
lip gloss350 products
serums & essences305 products
eye shadow256 products
bronzer/highlighter242 products
moisturizer with SPF239 products
eye liner219 products
brow liner190 products
conditioner190 products
mask186 products
exfoliant/scrub176 products
facial cleanser167 products
shampoo167 products
lip liner167 products
blush143 products
body oil140 products
body wash/cleanser131 products
hair treatment/serum115 products
mascara113 products
around-eye cream108 products
antiperspirant/deodorant107 products
hand cream91 products
makeup primer90 products
lip balm with SPF74 products
liquid hand soap73 products
body firming lotion73 products
hair styling aide64 products
facial powder61 products
bar soap54 products
anti-aging50 products
hair color and bleaching49 products
bath oil/salts/soak45 products
baby sunscreen44 products
baby lotion43 products
makeup remover41 products
toners/astringents36 products
beard oil34 products
styling gel/lotion33 products
lip plumper33 products
CC cream32 products
shaving cream29 products
diaper cream28 products
fragrance for women28 products
28 products
BB cream28 products
baby soap27 products
sunless tanning24 products
hair spray18 products
baby oil18 products
baby shampoo17 products
foot moisturizer17 products
fragrance for men15 products
shaving cream (men's)14 products
other eye makeup14 products
antiperspirant/deodorant (men's)13 products
hand sanitizer12 products
toothpaste12 products
baby wipes11 products
after shave10 products
cuticle treatment10 products
detangler10 products
beard care10 products
bubble bath9 products
vapor rubs9 products
eye makeup remover7 products
styling mousse/foam7 products
after sun product6 products
beard cleanser6 products
muscle/joint soreness6 products
nail treatment6 products
glitter5 products
body spray5 products
oil controller4 products
mouthwash4 products
damaged skin treatment3 products
depilatory2 products
baby bubble bath2 products
skin fading/lightener2 products
tanning oil2 products
foot cleansing2 products
baby powder2 products
foot odor control2 products
polish remover1 products
nail polish1 products
body powder1 products
eyelash glue1 products
tooth whitening1 products
body art1 products
setting powder/spray1 products

Contamination concerns

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Chemical
HYDROQUINONE

Cancer

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Concern Reference
Subcutaneously injection of Vitamin E induced formation of fast growing fibrosarcomata at the site of the injectionConstantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
43489 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Constantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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