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TOCOPHEROL

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick1339 products
foundation1215 products
lip balm814 products
facial moisturizer/treatment765 products
moisturizer703 products
concealer612 products
recreational sunscreen559 products
lip gloss464 products
serums & essences363 products
eye shadow342 products
eye liner291 products
bronzer/highlighter287 products
daily use with SPF286 products
mask273 products
conditioner265 products
brow liner260 products
exfoliant/scrub244 products
shampoo238 products
facial cleanser235 products
lip liner231 products
body oil202 products
hair treatment/serum193 products
blush188 products
antiperspirant/deodorant188 products
mascara182 products
around-eye cream168 products
body wash/cleanser164 products
body firming lotion163 products
hand cream140 products
makeup primer125 products
hair styling aide115 products
baby sunscreen106 products
liquid hand soap101 products
bar soap95 products
lip balm with SPF91 products
hair color and bleaching85 products
facial powder78 products
nail polish62 products
lip plumper61 products
makeup remover61 products
anti-aging60 products
bath oil/salts/soak59 products
baby lotion59 products
toners/astringents55 products
BB cream53 products
beard oil52 products
CC cream50 products
styling gel/lotion44 products
fragrance for women44 products
44 products
hand sanitizer37 products
shaving cream34 products
sunless tanning31 products
baby soap31 products
setting powder/spray29 products
diaper cream27 products
hair spray24 products
bubble bath24 products
foot moisturizer23 products
baby shampoo21 products
detangler21 products
antiperspirant/deodorant (men's)20 products
baby oil19 products
beard care19 products
muscle/joint soreness17 products
fragrance for men17 products
other eye makeup17 products
after sun product15 products
cuticle treatment14 products
body spray14 products
toothpaste14 products
styling mousse/foam13 products
after shave11 products
shaving cream (men's)11 products
nail treatment9 products
skin fading/lightener8 products
baby wipes8 products
vapor rubs8 products
glitter8 products
beard cleanser8 products
tanning oil7 products
eye makeup remover6 products
polish remover6 products
mouthwash6 products
oil controller5 products
baby bubble bath5 products
depilatory5 products
baby powder5 products
eyelash glue5 products
damaged skin treatment4 products
foot cleansing3 products
tooth whitening3 products
body powder3 products
body art3 products
hair removal waxes2 products
hair-loss treatment2 products
hair relaxer1 products

Contamination concerns

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Chemical
HYDROQUINONE

Cancer

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Concern Reference
Subcutaneously injection of Vitamin E induced formation of fast growing fibrosarcomata at the site of the injectionConstantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
43489 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Constantinides P, Harkey M 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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