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TITANIUM DIOXIDE

Score:

Data: Good

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Non-reproductive organ system toxicity (moderate) and Occupational hazards (high)

Cancer

Cancer concern is MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick1371 products
foundation1239 products
eye shadow669 products
concealer468 products
bronzer/highlighter371 products
lip gloss335 products
eye liner290 products
blush288 products
brow liner209 products
lip liner171 products
nail polish161 products
facial powder155 products
lip balm142 products
moisturizer with SPF93 products
BB cream75 products
mascara73 products
bar soap70 products
makeup with SPF64 products
mask63 products
facial moisturizer/treatment57 products
toothpaste55 products
makeup primer50 products
serums & essences40 products
lip balm with SPF37 products
moisturizer32 products
hair color and bleaching31 products
around-eye cream31 products
facial cleanser28 products
shampoo26 products
glitter26 products
exfoliant/scrub23 products
body wash/cleanser20 products
CC cream19 products
beach & sport sunscreen18 products
Facial Sun Care17 products
lip plumper16 products
body firming lotion16 products
shaving cream12 products
other eye makeup11 products
bath oil/salts/soak9 products
hair styling aide5 products
anti-aging5 products
baby lotion5 products
antiperspirant/deodorant4 products
styling gel/lotion4 products
sunless tanning3 products
body oil3 products
pore strips3 products
Oils & Serums3 products
body powder3 products
oil controller3 products
Lip Stain3 products
liquid hand soap2 products
shaving cream (men's)2 products
nail treatment2 products
tooth whitening2 products
baby soap2 products
conditioner2 products
fragrance for women2 products
toners/astringents1 products
baby oil1 products
baby sunscreen1 products
baby shampoo1 products
fragrance for men1 products
eyelash glue1 products
Under Eye Concealers1 products
hand cream1 products
baby toothpaste1 products

Occupational hazards

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Concern Reference
Allowed workplace exposures restricted to low dosesNational Library of Medicine HazMap

Cancer

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Concern Reference
Possible human carcinogenCalifornia EPA (California Environmental Protection Agency) 2012. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. Updated July 2012.
Limited evidence of carcinogenicityWorld Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 47, 93 ;in prep.
Limited evidence of carcinogenicityNIOSH Occupational Carcinogens

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as medium human health priorityEnvironment Canada Domestic Substance List

Decreased skin absorption

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Concern Reference
No absorption into intact skinGamer AO, Leibold E, et al (2006). "The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin." Toxicology in Vitro 20: 301-307.

Data gaps

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Concern Reference
21244 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Exempt from Batch Certification by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • California EPA (California Environmental Protection Agency) 2012. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. Updated July 2012.
  • World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 47, 93 ;in prep.
  • NIOSH (National Institute for Occupational Safety and Health). 2006. NIOSH Carcinogens List (Potential occupational carcinogens). http://www.cdc.gov/niosh/npotocca.html.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Gamer AO, Leibold E, et al (2006). "The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin." Toxicology in Vitro 20: 301-307.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.

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