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TITANIUM DIOXIDE

Score:

Data: Good

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Non-reproductive organ system toxicity (moderate) and Occupational hazards (high)

Cancer

Cancer concern is MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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foundation2306 products
lipstick2117 products
eye shadow1199 products
concealer856 products
bronzer/highlighter673 products
lip gloss642 products
eye liner486 products
blush475 products
brow liner418 products
lip liner279 products
facial powder257 products
nail polish246 products
lip balm231 products
bar soap184 products
toothpaste167 products
mask162 products
mascara155 products
makeup primer152 products
shampoo98 products
facial moisturizer/treatment88 products
moisturizer78 products
exfoliant/scrub77 products
hair color and bleaching66 products
facial cleanser63 products
body wash/cleanser62 products
serums & essences59 products
49 products
glitter48 products
around-eye cream46 products
BB cream45 products
lip plumper35 products
body firming lotion27 products
shaving cream23 products
hair styling aide20 products
conditioner19 products
CC cream17 products
tooth whitening11 products
moisturizer with SPF11 products
anti-aging10 products
pore strips9 products
other eye makeup9 products
sunless tanning8 products
hand cream8 products
bath oil/salts/soak8 products
nail treatment8 products
hair treatment/serum8 products
styling gel/lotion7 products
liquid hand soap5 products
shaving cream (men's)5 products
baby soap5 products
antiperspirant/deodorant5 products
lip balm with SPF5 products
baby lotion4 products
fragrance for women4 products
bubble bath4 products
baby shampoo4 products
oil controller3 products
makeup remover3 products
toners/astringents3 products
body oil3 products
baby oil2 products
hair relaxer2 products
body spray2 products
damaged skin treatment2 products
mouthwash2 products
baby toothpaste2 products
detangler2 products
styling mousse/foam2 products
depilatory1 products
eye makeup remover1 products
antiperspirant/deodorant (men's)1 products
beach & sport sunscreen1 products
after sun product1 products
foot cleansing1 products
baby bubble bath1 products
beard care1 products
setting powder/spray1 products
hair spray1 products
hand sanitizer1 products
foot moisturizer1 products
eyelash glue1 products
fragrance for men1 products

Occupational hazards

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Concern Reference
Allowed workplace exposures restricted to low dosesNational Library of Medicine HazMap

Cancer

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Concern Reference
Unbound particles of respirable size listed as a Carcinogen: California Proposition 65California EPA (California Environmental Protection Agency) 2012. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. Updated July 2012.
Limited evidence of carcinogenicityWorld Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 47, 93 ;in prep.
Limited evidence of carcinogenicityNIOSH Occupational Carcinogens

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as medium human health priorityEnvironment Canada Domestic Substance List

Decreased skin absorption

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Concern Reference
The amounts of titanium found in the tape strips and skin preparations were in the order of the analytical determination limit. No Ti was found in the receptor fluid at any sampling time.Gamer AO, Leibold E, et al (2006). "The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin." Toxicology in Vitro 20: 301-307.

Data gaps

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Concern Reference
21244 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Exempt from Batch Certification by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • California EPA (California Environmental Protection Agency) 2012. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. Updated July 2012.
  • World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 47, 93 ;in prep.
  • NIOSH (National Institute for Occupational Safety and Health). 2006. NIOSH Carcinogens List (Potential occupational carcinogens). http://www.cdc.gov/niosh/npotocca.html.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Gamer AO, Leibold E, et al (2006). "The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin." Toxicology in Vitro 20: 301-307.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.

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