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TITANIUM DIOXIDE

Score:

Data: Good

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Non-reproductive organ system toxicity (moderate) and Occupational hazards (high)

Cancer

Cancer concern is MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick1311 products
foundation1091 products
eye shadow618 products
concealer447 products
bronzer/highlighter345 products
lip gloss295 products
eye liner274 products
blush268 products
brow liner198 products
lip liner160 products
nail polish128 products
facial powder125 products
lip balm103 products
mascara66 products
bar soap54 products
mask50 products
makeup primer49 products
toothpaste44 products
serums & essences38 products
facial moisturizer/treatment35 products
hair color and bleaching30 products
moisturizer with SPF29 products
around-eye cream27 products
facial cleanser24 products
shampoo23 products
moisturizer22 products
glitter20 products
exfoliant/scrub19 products
lip plumper15 products
BB cream15 products
body wash/cleanser14 products
CC cream11 products
other eye makeup11 products
shaving cream10 products
bath oil/salts/soak9 products
hair styling aide5 products
anti-aging5 products
lip balm with SPF5 products
antiperspirant/deodorant4 products
body oil3 products
pore strips3 products
styling gel/lotion3 products
oil controller3 products
baby lotion3 products
shaving cream (men's)2 products
tooth whitening2 products
baby soap2 products
conditioner2 products
body powder2 products
liquid hand soap1 products
nail treatment1 products
toners/astringents1 products
sunless tanning1 products
baby oil1 products
baby sunscreen1 products
baby shampoo1 products
fragrance for men1 products
eyelash glue1 products
body firming lotion1 products
hand cream1 products
fragrance for women1 products
beach & sport sunscreen1 products
baby toothpaste1 products

Occupational hazards

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Concern Reference
Allowed workplace exposures restricted to low dosesNational Library of Medicine HazMap

Cancer

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Concern Reference
Possible human carcinogenCalifornia EPA (California Environmental Protection Agency) 2012. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. Updated July 2012.
Limited evidence of carcinogenicityWorld Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 47, 93 ;in prep.
Limited evidence of carcinogenicityNIOSH Occupational Carcinogens

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as medium human health priorityEnvironment Canada Domestic Substance List

Decreased skin absorption

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Concern Reference
No absorption into intact skinGamer AO, Leibold E, et al (2006). "The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin." Toxicology in Vitro 20: 301-307.

Data gaps

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Concern Reference
21244 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Exempt from Batch Certification by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • California EPA (California Environmental Protection Agency) 2012. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. Updated July 2012.
  • World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 47, 93 ;in prep.
  • NIOSH (National Institute for Occupational Safety and Health). 2006. NIOSH Carcinogens List (Potential occupational carcinogens). http://www.cdc.gov/niosh/npotocca.html.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Gamer AO, Leibold E, et al (2006). "The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin." Toxicology in Vitro 20: 301-307.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.

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