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MEXORYL SX

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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moisturizer with SPF1 products

Decreased skin absorption

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Concern Reference
Limited potential to absorb into the skin.Benech-Kieffer F, Meuling WJ, Leclerc C, Roza L, Leclaire J, Nohynek G 2003. Percutaneous absorption of Mexoryl SX in human volunteers: comparison with in vitro data. Skin pharmacology and applied skin physiology 16(6): 343-55.

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics

Cancer

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Concern Reference
One or more in vitro tests on mammalian cells show positive mutation resultsCantrell A, McGarvey D, Mulroy L, Truscott T 1999. Laser flash photolysis studies of the UVA sunscreen Mexoryl SX. Photochem Photobiol 70: 292-97.

Allergies/immunotoxicity

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Concern Reference
One or more human case studies show equivocal skin allergy or allergenic effectsFDA 2006. Center for Drug Evaluation and Research Application Number 21-502: Medical Review. Center for Drug Evaluation and Research, Food and Drug Administration. July 11, 2006.

Biochemical or cellular level changes

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Concern Reference
Does not produces excess reactive oxygen species or other harmful biochemical changes.Fourtanier A, Moyal D, Seite S 2008. Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results. Photodermatol Photoimmunol Photomed 24(4): 164-74.

Data gaps

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Concern Reference
44 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • Benech-Kieffer F, Meuling WJ, Leclerc C, Roza L, Leclaire J, Nohynek G 2003. Percutaneous absorption of Mexoryl SX in human volunteers: comparison with in vitro data. Skin pharmacology and applied skin physiology 16(6): 343-55.
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • Cantrell A, McGarvey D, Mulroy L, Truscott T 1999. Laser flash photolysis studies of the UVA sunscreen Mexoryl SX. Photochem Photobiol 70: 292-97.
  • FDA 2006. Center for Drug Evaluation and Research Application Number 21-502: Medical Review. Center for Drug Evaluation and Research, Food and Drug Administration. July 11, 2006.
  • Fourtanier A, Moyal D, Seite S 2008. Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results. Photodermatol Photoimmunol Photomed 24(4): 164-74.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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