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SULISOBENZONE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Endocrine disruption (low), and Non-reproductive organ system toxicity (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is MODERATE

Products with this Ingredient

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liquid hand soap15 products
shampoo6 products
serums & essences5 products
conditioner5 products
facial moisturizer/treatment4 products
body wash/cleanser3 products
styling gel/lotion3 products
makeup primer3 products
toners/astringents2 products
mask2 products
moisturizer1 products
moisturizer with SPF1 products
hand sanitizer1 products
bronzer/highlighter1 products
hair treatment/serum1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancerPont AR, Charron AR, Brand RM 2004. Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. Toxicol Appl Pharmacol 195(3): 348-354.
Absorbs into the skin{Couteau, 2001}

Allergies/immunotoxicity

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Concern Reference
Human skin toxicant or allergen - strong evidenceJACT 2(5):79-84, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005
Human skin toxicant or allergen - strong evidenceEWG Assessment of Open Scientific Literature
One or more human case studies show possible photoallergic or allergenic effectsHughes TM, Stone NM 2007. Benzophenone 4: an emerging allergen in cosmetics and toiletries? Contact Dermatitis 56(3): 153-156.
One or more human case studies show equivocal photoallergic or allergenic effectsRodriguez E, Valbuena MC, Rey M, Porras de Quintana L 2006. Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. Photodermatol Photoimmunol Photomed 22(4): 189-192.

Irritation (skin, eyes, or lungs)

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Concern Reference
Human any irritant - strong evidenceJACT 2(5):79-84, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005
Not likely to be a skin irritant in humans{IBL, 1967; Kligman, 1976; IBL 1962}

Organ system toxicity (non-reproductive)

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Concern Reference
One or more animal studies show sense effects at moderate doses (low dose studies may be unavailable for this ingredient){IBL, 1967; IBL, 1967; IBL 1962 ; ACC, 1959}
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient){ACC, 1959; IBL, 1962}
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Endocrine disruption

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Concern Reference
Associated with endocrine disruptionKunz PY, Galicia HF, Fent K 2006. Comparison of in vitro and in vivo estrogenic activity of UV filters in fish. Toxicol Sci 90(2): 349-361.

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productJACT 2(5):79-84, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005
13180 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Cancer

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Concern Reference
Not likely to be mutagenic in humans{CTFA, 1980; DHEW, 1978; Hill Top Research Labs, 1979; Litton Bioneics, 1979}

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyJACT 2(5):79-84, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Pont AR, Charron AR, Brand RM 2004. Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. Toxicol Appl Pharmacol 195(3): 348-354.
  • {Couteau, 2001}
  • JACT 2(5):79-84, 1983 confirmed 09/02 IJT 24(S1):10-18, 2005
  • EWG Assessment of Open Scientific Literature
  • Hughes TM, Stone NM 2007. Benzophenone 4: an emerging allergen in cosmetics and toiletries? Contact Dermatitis 56(3): 153-156.
  • Rodriguez E, Valbuena MC, Rey M, Porras de Quintana L 2006. Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. Photodermatol Photoimmunol Photomed 22(4): 189-192.
  • {IBL, 1967; Kligman, 1976; IBL 1962}
  • {IBL, 1967; IBL, 1967; IBL 1962 ; ACC, 1959}
  • {ACC, 1959; IBL, 1962}
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Kunz PY, Galicia HF, Fent K 2006. Comparison of in vitro and in vivo estrogenic activity of UV filters in fish. Toxicol Sci 90(2): 349-361.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • {CTFA, 1980; DHEW, 1978; Hill Top Research Labs, 1979; Litton Bioneics, 1979}

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