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SODIUM FLUORIDE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate), Non-reproductive organ system toxicity (low), Multiple, additive exposure sources (high), Irritation (skin, eyes, or lungs) (high), and Occupational hazards (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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toothpaste20 products
mouthwash10 products
tooth whitening3 products
baby toothpaste1 products

Multiple, additive exposure sources

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Concern Reference
Used in food or as an additive with limited or no toxicity information availableFDA Everything Added to Food
Designated as safe for general or specific, limited use in foodFDA Food Additive Status

Occupational hazards

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Concern Reference
Allowed workplace exposures restricted to very low dosesCPS&Q - Classification & Labelling
Allowed workplace exposures restricted to low dosesCPS&Q - Classification & Labelling

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - anyCosIng

Developmental/reproductive toxicity

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Concern Reference
Limited evidence of developmental toxicityJankovic, J A Screening Method for Occupational Reproductive Health Risk. American Industrial Hygiene Association Journal. 57: 641-649. 1996.

Organ system toxicity (non-reproductive)

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Concern Reference
Limited evidence of musculoskeletal toxicityAgency for Toxic Substances and Disease Registry Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
Classified as a low human health priorityEnvironment Canada Domestic Substance List

Miscellaneous

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Concern Reference
Occupational hazards related to handlingCPS&Q - Classification & Labelling

Data gaps

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Concern Reference
8654 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • Jankovic, J A Screening Method for Occupational Reproductive Health Risk. American Industrial Hygiene Association Journal. 57: 641-649. 1996.
  • Agency for Toxic Substances and Disease Registry Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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