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SD ALCOHOL 40B

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Non-reproductive organ system toxicity (low), and Multiple, additive exposure sources (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW_MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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beach & sport sunscreen49 products
moisturizer with SPF13 products
blush7 products
foundation3 products
shampoo3 products
hair spray3 products
fragrance for women3 products
BB cream3 products
antiperspirant/deodorant2 products
facial moisturizer/treatment2 products
serums & essences2 products
facial cleanser1 products
moisturizer1 products
toners/astringents1 products
makeup with SPF1 products
after shave1 products
mask1 products
mascara1 products
oil controller1 products
hair color and bleaching1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancerCosmetic Ingredient Review Assessments
Penetration enhancerMutalik S, Udupa N "Effect of some penetration enhancers on the permeation of glibenclamide and glipizide through mouse skin." Pharmazie. 2003 Dec;58(12):891-4. ; Brand RM, Jendrzejewski JL, Henery EM, Charron AR. A single oral dose of ethanol can alter transdermal absorption of topically applied chemicals in rats. Toxicol Sci. 2006 Aug;92(2):349-55. Epub 2006 May 5.

Multiple, additive exposure sources

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Concern Reference
Used in food or as an additive with limited or no toxicity information availableFDA Everything Added to Food

Developmental/reproductive toxicity

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Concern Reference
Limited evidence of reproductive toxicityNational Library of Medicine HazMap
Limited evidence of reproductive toxicityFrazier , L and M. L. Hage (eds.). Reproductive Hazards of the Workplace, Wiley Europe, 1998. Table 10 (Partial List of Reproductive Toxicants) available at http://www.pharmacy.ohio-state.edu/homepage/safety/chemhygiene_table_repro.pdf.

Cancer

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Concern Reference
Cancer - limited evidenceA Relational Database of Hazardous Chemicals and Occupational Diseases Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html; National Toxicology Program. 10th Report on Carcinogens (2002). http://ehis.niehs.nih.gov/roc/toc10.html

Organ system toxicity (non-reproductive)

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Concern Reference
Limited evidence of gastrointestinal or liver toxicityNational Library of Medicine HazMap
Limited evidence of sense organ toxicityHarvell, J, M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).
reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyNational Library of Medicine HazMap

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
1 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Miscellaneous

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Concern Reference
Occupational hazards related to handlingCPS&Q - Classification & Labelling

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Neurotoxicity

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Concern Reference
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyNational Library of Medicine HazMap

Data Sources

  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • Mutalik S, Udupa N "Effect of some penetration enhancers on the permeation of glibenclamide and glipizide through mouse skin." Pharmazie. 2003 Dec;58(12):891-4. ; Brand RM, Jendrzejewski JL, Henery EM, Charron AR. A single oral dose of ethanol can alter transdermal absorption of topically applied chemicals in rats. Toxicol Sci. 2006 Aug;92(2):349-55. Epub 2006 May 5.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • Frazier , L and M. L. Hage (eds.). Reproductive Hazards of the Workplace, Wiley Europe, 1998. Table 10 (Partial List of Reproductive Toxicants) available at http://www.pharmacy.ohio-state.edu/homepage/safety/chemhygiene_table_repro.pdf.
  • A Relational Database of Hazardous Chemicals and Occupational Diseases Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html; National Toxicology Program. 10th Report on Carcinogens (2002). http://ehis.niehs.nih.gov/roc/toc10.html
  • Harvell, J, M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.

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