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RETINYL PROPIONATE

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Non-reproductive organ system toxicity (low), and Biochemical or cellular level changes (high)

Cancer

Cancer concern is LOW_MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is HIGH

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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facial moisturizer/treatment11 products
serums & essences5 products
around-eye cream3 products
body wash/cleanser3 products
anti-aging2 products
moisturizer1 products
mask1 products
conditioner1 products
1 products
facial cleanser1 products
toners/astringents1 products

Biochemical or cellular level changes

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Concern Reference
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.Open scientific literature

Developmental/reproductive toxicity

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Concern Reference
Known human reproductive toxicantOpen scientific literature
Limited evidence of reproductive toxicityOpen scientific literature
One or more animal studies show reproductive effects at low dosesOpen scientific literature

Enhanced skin absorption

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Concern Reference
Absorbs into the skinOpen scientific literature

Use restrictions

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Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsOpen scientific literature
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients

Cancer

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Concern Reference
One or more animal studies show tumor formation at very low dosesOpen scientific literature
Cancer - limited evidenceOpen scientific literature
One or more in vitro tests on mammalian cells show positive mutation resultsOpen scientific literature
One or more in vitro tests non-mammalian cells show positive mutation resultsOpen scientific literature

Organ system toxicity (non-reproductive)

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Concern Reference
Limited evidence of skin toxicityOpen scientific literature
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Ecotoxicology

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Concern Reference
Uncertain environmental toxin and uncertain persistent or bioaccumulativeEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
10 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List

Data Sources

  • Open scientific/peer reviewed literature
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

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