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RETINYL PALMITATE (VITAMIN A PALMITATE)

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Non-reproductive organ system toxicity (low), and Biochemical or cellular level changes (high)

Cancer

Cancer concern is LOW_MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is HIGH

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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foundation258 products
lipstick201 products
moisturizer167 products
concealer149 products
facial moisturizer/treatment103 products
conditioner88 products
serums & essences62 products
daily use with SPF57 products
exfoliant/scrub56 products
lip gloss53 products
facial cleanser46 products
hair treatment/serum44 products
recreational sunscreen44 products
mask42 products
shampoo39 products
around-eye cream31 products
makeup primer24 products
body wash/cleanser23 products
facial powder22 products
hand cream22 products
anti-aging21 products
body firming lotion20 products
CC cream18 products
lip plumper17 products
hair styling aide17 products
setting powder/spray15 products
14 products
blush12 products
eye liner11 products
bronzer/highlighter11 products
brow liner11 products
BB cream11 products
mascara10 products
nail treatment9 products
body oil8 products
toners/astringents8 products
hair spray8 products
lip balm8 products
after sun product7 products
baby sunscreen7 products
hair color and bleaching6 products
liquid hand soap6 products
foot moisturizer6 products
nail polish6 products
eye shadow5 products
hair-loss treatment5 products
styling gel/lotion4 products
toothpaste4 products
bath oil/salts/soak4 products
muscle/joint soreness4 products
after shave4 products
tanning oil4 products
bar soap4 products
baby shampoo4 products
baby soap4 products
baby lotion4 products
skin fading/lightener3 products
diaper cream3 products
sunless tanning3 products
cuticle treatment3 products
polish remover3 products
shaving cream (men's)3 products
detangler3 products
styling mousse/foam2 products
bubble bath2 products
baby oil2 products
shaving cream2 products
body powder2 products
foot cleansing2 products
makeup remover2 products
lip balm with SPF2 products
baby bubble bath2 products
lip liner1 products
hand sanitizer1 products
tooth whitening1 products
damaged skin treatment1 products
pore strips1 products
beard cleanser1 products

Use restrictions

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Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsOpen scientific literature
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients

Biochemical or cellular level changes

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Concern Reference
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.Open scientific literature

Developmental/reproductive toxicity

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Concern Reference
Known human reproductive toxicantOpen scientific literature
Limited evidence of reproductive toxicityOpen scientific literature
One or more animal studies show reproductive effects at low dosesOpen scientific literature

Enhanced skin absorption

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Concern Reference
Absorbs into the skinOpen scientific literature

Cancer

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Concern Reference
One or more animal studies show tumor formation at very low dosesOpen scientific literature
Cancer - limited evidenceOpen scientific literature
One or more in vitro tests on mammalian cells show positive mutation resultsOpen scientific literature
One or more in vitro tests non-mammalian cells show positive mutation resultsOpen scientific literature

Organ system toxicity (non-reproductive)

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Concern Reference
Limited evidence of skin toxicityOpen scientific literature
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
1692 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Uncertain environmental toxin and uncertain persistent or bioaccumulativeEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List
Not suspected to be persistentEnvironment Canada Domestic Substance List

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Data Sources

  • Open scientific/peer reviewed literature
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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