IMAGE SOURCE: PubChem
Other ConcernsUse restrictions (high), Non-reproductive organ system toxicity (low), and Biochemical or cellular level changes (high)
Unacceptable: EWG VERIFIED products cannot contain this ingredient
FDA and German health agency have raised a concern that daily skin application of vitamin A creams may contribute to excessive vitamin A intake for pregnant women and other populations.
See how this product scores for common concerns.
LOWAllergies & Immunotoxicity
HIGHDevelopmental and Reproductive Toxicity
- DATA SOURCES
Products with this Ingredient
Biochemical or cellular level changes
|Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.||Open scientific literature|
|Violation of government restrictions - Banned or found unsafe for use in cosmetics||Open scientific literature|
|Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics||Canada - Prohibited and Restricted Cosmetics Ingredients|
Enhanced skin absorption
|Absorbs into the skin||Open scientific literature|
|Known human reproductive toxicant||Open scientific literature|
|Limited evidence of reproductive toxicity||Open scientific literature|
|One or more animal studies show reproductive effects at low doses||Open scientific literature|
|One or more animal studies show tumor formation at very low doses||Open scientific literature|
|Cancer - limited evidence||Open scientific literature|
|One or more in vitro tests on mammalian cells show positive mutation results||Open scientific literature|
|One or more in vitro tests non-mammalian cells show positive mutation results||Open scientific literature|
Organ system toxicity (non-reproductive)
|Limited evidence of skin toxicity||Open scientific literature|
|Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product||Cosmetic Ingredient Review Assessments|
|18 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
|Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any||Cosmetic Ingredient Review Assessments|
- Open scientific/peer reviewed literature
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.
Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.HOW WE DETERMINE SCORES
The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.
The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.