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QUILLAJA SAPONARIA (SOAPBARK) BARK EXTRACT

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Non-reproductive organ system toxicity (low) and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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foundation21 products
shampoo12 products
facial cleanser10 products
baby bubble bath9 products
baby shampoo9 products
baby soap8 products
conditioner8 products
body wash/cleanser5 products
hair styling aide5 products
toners/astringents5 products
styling gel/lotion4 products
moisturizer3 products
foot moisturizer2 products
hair treatment/serum2 products
anti-aging2 products
makeup remover1 products
exfoliant/scrub1 products
sunless tanning1 products
body firming lotion1 products
eye makeup remover1 products
mask1 products
toothpaste1 products
mouthwash1 products
hair-loss treatment1 products
CC cream1 products
facial moisturizer/treatment1 products

Allergies/immunotoxicity

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Concern Reference
Components of Q. saponaria (saponins) can impact immune function.Juliane Deise Fleck, Andresa Heemann Betti, Francini Pereira da Silva, Eduardo Artur Troian, Cristina Olivaro, Fernando Ferreira & Simone Gasparin Verza 2019. Saponins from Quillaja saponaria and Quillaja brasiliensis: Particular Chemical Characteristics and Biological Activities. Molecules (Basel, Switzerland) 24(1).

Irritation (skin, eyes, or lungs)

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Concern Reference
REACH registrations this substance may cause respiratory irritation.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Quillaja saponaria, ext.; (3S,4S,6R)-6-{[(3S,4S,6aR,6bS,8R,8aR,12aS,14bR)-8a-({[(2S,4S,5S)-5-(acetyloxy)-3-{[(2S,4R,5R)-3,4-dihydroxy-6-methyl-5-{[(2S,4R,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}oxan-2-yl]oxy}-6-methyl-4-{[(2S,4S,5R)-3,4,5-trihydroxy-6-methy; cas_numbers: 68990-67-0
REACH registrations this substance causes serious eye damage.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Quillaja saponaria, ext.; (3S,4S,6R)-6-{[(3S,4S,6aR,6bS,8R,8aR,12aS,14bR)-8a-({[(2S,4S,5S)-5-(acetyloxy)-3-{[(2S,4R,5R)-3,4-dihydroxy-6-methyl-5-{[(2S,4R,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}oxan-2-yl]oxy}-6-methyl-4-{[(2S,4S,5R)-3,4,5-trihydroxy-6-methy; cas_numbers: 68990-67-0

Organ system toxicity (non-reproductive)

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Concern Reference
Components of Q. saponaria (saponins) can cause hemolysis and damage other cells.Juliane Deise Fleck, Andresa Heemann Betti, Francini Pereira da Silva, Eduardo Artur Troian, Cristina Olivaro, Fernando Ferreira & Simone Gasparin Verza 2019. Saponins from Quillaja saponaria and Quillaja brasiliensis: Particular Chemical Characteristics and Biological Activities. Molecules (Basel, Switzerland) 24(1).
REACH registrations this substance is toxic if inhaled.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Quillaja saponaria, ext.; (3S,4S,6R)-6-{[(3S,4S,6aR,6bS,8R,8aR,12aS,14bR)-8a-({[(2S,4S,5S)-5-(acetyloxy)-3-{[(2S,4R,5R)-3,4-dihydroxy-6-methyl-5-{[(2S,4R,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}oxan-2-yl]oxy}-6-methyl-4-{[(2S,4S,5R)-3,4,5-trihydroxy-6-methy; cas_numbers: 68990-67-0

Ecotoxicology

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Concern Reference
Extracts and components of Q. saponaria (saponins) were toxic to aquatic organisms.Juliane Deise Fleck, Andresa Heemann Betti, Francini Pereira da Silva, Eduardo Artur Troian, Cristina Olivaro, Fernando Ferreira & Simone Gasparin Verza 2019. Saponins from Quillaja saponaria and Quillaja brasiliensis: Particular Chemical Characteristics and Biological Activities. Molecules (Basel, Switzerland) 24(1).

Data gaps

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Concern Reference
108 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Data Sources

  • Juliane Deise Fleck, Andresa Heemann Betti, Francini Pereira da Silva, Eduardo Artur Troian, Cristina Olivaro, Fernando Ferreira & Simone Gasparin Verza 2019. Saponins from Quillaja saponaria and Quillaja brasiliensis: Particular Chemical Characteristics and Biological Activities. Molecules (Basel, Switzerland) 24(1).
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Quillaja saponaria, ext.; (3S,4S,6R)-6-{[(3S,4S,6aR,6bS,8R,8aR,12aS,14bR)-8a-({[(2S,4S,5S)-5-(acetyloxy)-3-{[(2S,4R,5R)-3,4-dihydroxy-6-methyl-5-{[(2S,4R,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}oxan-2-yl]oxy}-6-methyl-4-{[(2S,4S,5R)-3,4,5-trihydroxy-6-methy; cas_numbers: 68990-67-0
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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