Other ConcernsUse restrictions (moderate), Non-reproductive organ system toxicity (moderate), Irritation (skin, eyes, or lungs) (moderate), and Contamination concerns (high)
SYNONYMS1-(3-CHLORO-2-PROPENYL)- 3,5,7-TRIAZA-1-AZONIATRICYCLO[22.214.171.124]DECANE, 1-(3-CHLORO-2-PROPENYL)-3,5,7-TRIAZA-1-AZONIATRICYCLO[126.96.36.199]DECANE CHLORIDE, 1-(3-CHLOROALLYL)-3,5,7-TRIAZA-1-AZONIAADAMANTANE CHLORIDE, 3,5,7-TRIAZA-1-AZONIATRICYCLO[188.8.131.52]DECANE, 1-(3-CHLORO-2-PROPENYL)-, 3,5,7TRIAZA1AZONIATRICYCLO[184.108.40.206,7]DECANE, 1(3CHLORO2PROPENYL), CHLORIDE, CHLOROALLYL METHENAMINE CHLORIDE, METHENAMINE 3-CHLOROALLY LCHLORIDE, METHENAMINE 3-CHLOROALLYLOCHLORIDE, N-(3-CHLOROALLYL)HEXAMINIUM CHLORIDE, QUATERNIUM-15, and QUATERNIUM-15 (FORMALDEHYDE RELEASER)
Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation
This ingredient is a quaternary ammonium salt used as a preservative; it acts as a formaldehyde releaser. The European Union has determined that this ingredient 'may not be safe' in cosmetics.
See how this product scores for common concerns.
HIGHAllergies & Immunotoxicity
LOWDevelopmental and Reproductive Toxicity
- DATA SOURCES
Products with this Ingredient
|Known human skin sensitizer toxicant or allergen||Open scientific literature|
|Human skin toxicant or allergen - strong evidence||Cosmetic Ingredient Review Assessments|
|Limited evidence of immune system toxicity or allergies||National Library of Medicine HazMap|
Irritation (skin, eyes, or lungs)
|Possible human eye, skin irritant||Open scientific literature|
|Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - any||Open scientific literature|
|Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications||Cosmetic Ingredient Review Assessments|
Organ system toxicity (non-reproductive)
|Classified as expected to be toxic or harmful||Environment Canada Domestic Substance List|
|Classified as medium human health priority||Environment Canada Domestic Substance List|
|One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)||EPA Toxic Release Inventory PBTs|
|Cancer - limited evidence||Open scientific literature|
|One or more animal studies show any effects at moderate doses||Open scientific literature|
|Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product||Cosmetic Ingredient Review Assessments|
|94 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
|Not suspected to be an environmental toxin||Environment Canada Domestic Substance List|
Persistence and bioaccumulation
|Not suspected to be bioaccumulative||Environment Canada Domestic Substance List|
|Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Determined safe for use in cosmetics up to a specified concentration limit||Cosmetic Ingredient Review Assessments|
- Open scientific/peer reviewed literature
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.
Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.HOW WE DETERMINE SCORES
The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.
The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.