EWG Skin Deep® | What is PROLINE

HOW WE DETERMINE SCORES Learn more About EWG VERIFIED™

Data: Fair

Proline

IMAGE SOURCE: PubChem

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Other Concerns

SYNONYMS

● DL-PROLINE

● L-PROLINE

● PROLINE

Restricted

Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation

This ingredient can contain either D, L, or DL-proline, an amino acid. L-proline is the isomer of proline found in proteins.

Common concerns

See how this product scores for common concerns.

LOW

Cancer
LOW

Allergies & Immunotoxicity
LOW

Developmental and Reproductive Toxicity
LOW

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

foundation	89 products
facial moisturizer/treatment	43 products
conditioner	36 products
shampoo	35 products
mask	26 products
serums & essences	24 products
hair treatment/serum	17 products
facial cleanser	17 products
around-eye cream	14 products
hair styling aide	13 products
body wash/cleanser	12 products
moisturizer	10 products
exfoliant/scrub	10 products
hair color and bleaching	7 products
toners/astringents	7 products
liquid hand soap	5 products
makeup remover	4 products
body firming lotion	4 products
damaged skin treatment	3 products
styling gel/lotion	3 products
hand cream	3 products
other eye makeup	2 products
anti-aging	2 products
daily use with SPF	2 products
hair spray	2 products
mascara	2 products
hair-loss treatment	2 products
foot cleansing	1 products
after sun product	1 products
styling mousse/foam	1 products
recreational sunscreen	1 products
beard care	1 products
brow liner	1 products
bar soap	1 products
shaving cream	1 products
diaper cream	1 products
detangler	1 products
makeup primer	1 products

Multiple, additive exposure sources

CONCERN	REFERENCE
Designated as safe for general or specific, limited use in food	FDA Food Additive Status
Designated as safe for general or specific, limited use in food	FDA Everything Added to Food

Ecotoxicology

CONCERN	REFERENCE
Not suspected to be an environmental toxin	Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Classified as not expected to be potentially toxic or harmful	Environment Canada Domestic Substance List

Persistence and bioaccumulation

CONCERN	REFERENCE
Not suspected to be persistent	Environment Canada Domestic Substance List
Not suspected to be bioaccumulative	Environment Canada Domestic Substance List

Data gaps

CONCERN	REFERENCE
40209 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

Informational

CONCERN	REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any	Open scientific literature

FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Open scientific/peer reviewed literature

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST

Low Availability

Moderate Availability

High Availability