- Products with the EWG VERIFIED mark have met the program’s impurity and use restrictions based on EWG's review of the company's data.
Other ConcernsUse restrictions (low), Non-reproductive organ system toxicity (low), Irritation (skin, eyes, or lungs) (low), and Contamination concerns (high)
SYNONYMSMONOHEXADECANOATE POLY(OXY-1,2-ETHANEDIYL) DERIVS. SORBITAN, MONOHEXADECANOATE SORBITAN, POLY(OXY-1,2-ETHANEDIYL) DERIVS, POLY(OXY-1,2-ETHANEDIYL) DERIVS. SORBITAN, MONOHEXADECANOATE, POLYOXYETHYLENE (20) SORBITAN MONOPALMITATE, POLYOXYETHYLENE SORBITAN MONOPALMITATE, POLYSORBATE 40, POLYSORBATE-40, SORBIMACROGOL PALMITATE 300, SORBITAN, MONOHEXADECANOATE, POLY(OXY-1,2-ETHANEDIYL) DERIVS., and SORBITAN, MONOHEXADECANOATE, POLY(OXY1,2ETHANEDIYL) DERIVS.
Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation
Polysorbate 40 is a mixture of palmitate esters of sorbitol and sorbitol anhydrides, consistingpredominantly of the monoester, condensed with approximately 20 moles of ethylene oxide.
See how this product scores for common concerns.
LOWAllergies & Immunotoxicity
LOWDevelopmental and Reproductive Toxicity
- DATA SOURCES
Products with this Ingredient
Organ system toxicity (non-reproductive)
|Limited evidence of sense organ toxicity||Scorecard.org Toxicity Information|
|Classified as not expected to be potentially toxic or harmful||Environment Canada Domestic Substance List|
|Classified as a low human health priority||Environment Canada Domestic Substance List|
|Determined safe for use in cosmetics, subject to concentration or use limitations - any||Open scientific literature|
Irritation (skin, eyes, or lungs)
|any irritation - weight of evidence unknown/unassessed||Open scientific literature|
|Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product||Cosmetic Ingredient Review Assessments|
|185 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
Multiple, additive exposure sources
|Designated as safe for general or specific, limited use in food||FDA Food Additive Status|
|Designated as safe for general or specific, limited use in food||FDA Everything Added to Food|
|Not suspected to be an environmental toxin||Environment Canada Domestic Substance List|
|Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any||Cosmetic Ingredient Review Assessments|
- ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- Open scientific/peer reviewed literature
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
- FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.
Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.HOW WE DETERMINE SCORES
The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.
The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.