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Data: Limited

Polysorbate 40

  • Products with the EWG VERIFIED mark have met the program’s impurity and use restrictions based on EWG's review of the company's data.

IMAGE SOURCE: PubChem

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Other Concerns

Use restrictions (low), Non-reproductive organ system toxicity (low), Irritation (skin, eyes, or lungs) (low), and Contamination concerns (high)

SYNONYMS

MONOHEXADECANOATE POLY(OXY-1,2-ETHANEDIYL) DERIVS. SORBITAN, MONOHEXADECANOATE SORBITAN, POLY(OXY-1,2-ETHANEDIYL) DERIVS, POLY(OXY-1,2-ETHANEDIYL) DERIVS. SORBITAN, MONOHEXADECANOATE, POLYOXYETHYLENE (20) SORBITAN MONOPALMITATE, POLYOXYETHYLENE SORBITAN MONOPALMITATE, POLYSORBATE 40, POLYSORBATE-40, SORBIMACROGOL PALMITATE 300, SORBITAN, MONOHEXADECANOATE, POLY(OXY-1,2-ETHANEDIYL) DERIVS., and SORBITAN, MONOHEXADECANOATE, POLY(OXY1,2ETHANEDIYL) DERIVS.

Restricted

Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation


Polysorbate 40 is a mixture of palmitate esters of sorbitol and sorbitol anhydrides, consistingpredominantly of the monoester, condensed with approximately 20 moles of ethylene oxide.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • LOW
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • LOW
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

Expand content Collapse content
moisturizer33 products
facial moisturizer/treatment7 products
body firming lotion5 products
makeup primer2 products
around-eye cream1 products
mask1 products

Contamination concerns

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Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Limited evidence of sense organ toxicityScorecard.org Toxicity Information
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
Classified as a low human health priorityEnvironment Canada Domestic Substance List

Use restrictions

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CONCERN REFERENCE
Determined safe for use in cosmetics, subject to concentration or use limitations - anyOpen scientific literature

Irritation (skin, eyes, or lungs)

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CONCERN REFERENCE
any irritation - weight of evidence unknown/unassessedOpen scientific literature

Data gaps

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CONCERN REFERENCE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
185 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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CONCERN REFERENCE
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Ecotoxicology

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CONCERN REFERENCE
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments
  • ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Open scientific/peer reviewed literature
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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