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Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate), Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), and Contamination concerns (high)


Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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Contamination concerns

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Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients

Organ system toxicity (non-reproductive)

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Concern Reference
Potential risk of infectious disease - anyFDA Ingredients with Bovine Spongiform Encephalopathy Concern
Potential risk of infectious disease - Must be free of detectable pathogenic viruses or infectious agentsCosmetic Ingredient Review Assessments

Endocrine disruption

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Concern Reference
One or more studies show weak endocrine disruptionTiwary, C M. (1998). "Premature sexual development in children following the use of estrogen- or placenta-containing hair products." Clin Pediatr (Phila) 37(12): 733-9.
endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyCosmetic Ingredient Review Assessments

Data gaps

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Concern Reference
Insufficient data to determine safetyCosmetic Ingredient Review Assessments
223 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed


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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - endocrineCosmetic Ingredient Review Assessments

Data Sources

  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • FDA (U.S. Food and Drug Administration). 2000. FDA Center for Food Safety and Applied Nutrition. Cosmetics Compliance Program. Domestic Cosmetics Program. Coverage of Bovine-Derived Ingredients for Bovine Spongiform Encephalopathy (BSE). Issued July 31, 2000.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • Tiwary, C M. (1998). "Premature sexual development in children following the use of estrogen- or placenta-containing hair products." Clin Pediatr (Phila) 37(12): 733-9.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data.


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