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PLACENTAL EXTRACT
Score:
Data: Limited
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate), Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), and Contamination concerns (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
Contamination concerns
| Chemical |
|---|
| PROGESTERONE |
| ESTROGEN |
| ESTRONE |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Potential risk of infectious disease - any | FDA Ingredients with Bovine Spongiform Encephalopathy Concern |
| Potential risk of infectious disease - Must be free of detectable pathogenic viruses or infectious agents | Cosmetic Ingredient Review Assessments |
Endocrine disruption
| Concern | Reference |
|---|---|
| One or more studies show weak endocrine disruption | Tiwary, C M. (1998). "Premature sexual development in children following the use of estrogen- or placenta-containing hair products." Clin Pediatr (Phila) 37(12): 733-9. |
| endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox study | Cosmetic Ingredient Review Assessments |
Data gaps
| Concern | Reference |
|---|---|
| Insufficient data to determine safety | Cosmetic Ingredient Review Assessments |
| 223 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - endocrine | Cosmetic Ingredient Review Assessments |
Data Sources
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- FDA (U.S. Food and Drug Administration). 2000. FDA Center for Food Safety and Applied Nutrition. Cosmetics Compliance Program. Domestic Cosmetics Program. Coverage of Bovine-Derived Ingredients for Bovine Spongiform Encephalopathy (BSE). Issued July 31, 2000.
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- Tiwary, C M. (1998). "Premature sexual development in children following the use of estrogen- or placenta-containing hair products." Clin Pediatr (Phila) 37(12): 733-9.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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