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Data: Fair

Padimate O

IMAGE SOURCE: PubChem

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Other Concerns

Enhanced skin absorption, Use restrictions (moderate), Endocrine disruption (low), Contamination concerns (high), and Biochemical or cellular level changes (high)

SYNONYMS

● 2-ETHYLHEXYL 4-(DIMETHYLAMINO)BENZOATE
● 2-ETHYLHEXYL 4-DIMETHYL-AMINOBENZOATE
● 2-ETHYLHEXYL ESTER 4-(DIMETHYLAMINO)BENZOIC ACID
● 2-ETHYLHEXYL ESTER BENZOIC ACID, 4-(DIMETHYLAMINO)-
● 2-ETHYLHEXYL P-DIMETHYLAMINOBENZOATE
● 2-ETHYLHEXYL PARADIMETHYLAMINO BENZOATE
● 4-(DIMETHYLAMINO)- 2-ETHYLHEXYL ESTER BENZOIC ACID
● 4-(DIMETHYLAMINO)- OCTYL ESTER BENZOIC ACID
● 4-(DIMETHYLAMINO)BENZOIC ACID, 2-ETHYLHEXYL ESTER
● ARLATONE UVB
● BENZOIC ACID, 4(DIMETHYLAMINO), 2ETHYLHEXYL ESTER
● BENZOIC ACID, 4-(DIMETHYLAMINO)-, 2-ETHYLHEXYL ESTER
● BENZOIC ACID, 4-(DIMETHYLAMINO)-, OCTYL ESTER
● BENZOIC ACID, P-(DIMETHYLAMINO)-, 2-ETHYLHEXYL ESTER
● CARALOE SNOW & SUN LIP BALM
● EINECS 244-289-3
● ESCALOL 507
● ETHYLHEXYL DIMETHYL PABA
● EUSOLEX 6007
● HSDB 7169
● OCTY L DIMETHYL PABA
● OCTYL DIMETHYL P-AMINOBENZOATE
● OCTYL DIMETHYL PABA
● OCTYL ESTER BENZOIC ACID, 4-(DIMETHYLAMINO)-
● PADIMATE O
● PADIMATE O (OCTYL DIMETHYL PABA | PABA ESTER)
● PADIMATE-O
● PHOTOPLEX
● PO
● PRESUN 15
● PRESUN 46
● RADIACARE LIP BALM

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient


A derivative of the once-popular PABA sunscreen ingredient, research shows this chemical releases free radicals, damages DNA, has estrogenic activity, and causes allergic reactions in some people.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • LOW
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • MODERATE
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

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hair treatment/serum4 products
hair spray3 products
conditioner3 products
serums & essences1 products
lip balm with SPF1 products
moisturizer1 products
facial moisturizer/treatment1 products

Contamination concerns

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Chemical
NITROSAMINES

Enhanced skin absorption

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CONCERN REFERENCE
Penetration enhancerOpen scientific literature

Biochemical or cellular level changes

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CONCERN REFERENCE
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.Open scientific literature

Use restrictions

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CONCERN REFERENCE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics

Endocrine disruption

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CONCERN REFERENCE
One or more studies show weak endocrine disruptionOpen scientific literature

Cancer

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CONCERN REFERENCE
One or more in vitro tests on mammalian cells show positive mutation resultsOpen scientific literature

Allergies/immunotoxicity

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CONCERN REFERENCE
Associated with immunotoxicity or allergiesOpen scientific literature

Ecotoxicology

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CONCERN REFERENCE
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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CONCERN REFERENCE
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data gaps

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CONCERN REFERENCE
20352 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed
  • Open scientific/peer reviewed literature
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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