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PADIMATE O

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Use restrictions (moderate), Endocrine disruption (low), Contamination concerns (high), and Biochemical or cellular level changes (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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hair spray1 products

Contamination concerns

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Chemical
NITROSAMINES

Enhanced skin absorption

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Concern Reference
Penetration enhancer{Krishnan, 2004}

Biochemical or cellular level changes

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Concern Reference
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.{Allen, 1996}

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics

Cancer

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Concern Reference
One or more in vitro tests on mammalian cells show positive mutation results{Gulston, 1999}

Endocrine disruption

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Concern Reference
One or more studies show weak endocrine disruption{Gomez, 2005}

Allergies/immunotoxicity

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Concern Reference
Associated with immunotoxicity or allergiesRodriguez E, Valbuena MC, Rey M, Porras de Quintana L 2006. Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. Photodermatol Photoimmunol Photomed 22(4): 189-192.

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
20352 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • {Krishnan, 2004}
  • {Allen, 1996}
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • {Gulston, 1999}
  • {Gomez, 2005}
  • Rodriguez E, Valbuena MC, Rey M, Porras de Quintana L 2006. Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. Photodermatol Photoimmunol Photomed 22(4): 189-192.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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