Other ConcernsEnhanced skin absorption, Use restrictions (moderate), Endocrine disruption (moderate), Persistence and bioaccumulation (low), Non-reproductive organ system toxicity (low), and Biochemical or cellular level changes (high)
SYNONYMS(2-HYDROXY-4-METHOXYPHENYL)PHENYL- METHANONE, (2-HYDROXY-4-METHOXYPHENYL)PHENYLMETHANONE, 2-BENZOYL-5-METHOXYPHENOL, 2-HYDROXY-4-METHOXYBENZOPHENONE, 4-08-00-02442 (BEILSTEIN HANDBOOK REFERENCE), 4-METHOXY-2-HYDROXYBENZOPHENONE, ADVASTAB 45, AI3-23644, ANUVEX, B3, BENZOPHENONE, 2-HYDROXY-4-METHOXY-, BENZOPHENONE-3, BRN 1913145, CCRIS 1078, CHIMASSORB 90, CYASORB UV 9, CYASORB UV 9 LIGHT ABSORBER, DURASCREEN, EINECS 205-031-5, ESCALOL 567, HMBP, HSDB 4503, METHANONE, (2-HYDROXY-4-METHOXYPHENYL)PHENYL-, METHANONE, (2HYDROXY4METHOXYPHENYL)PHENYL, MOB, MOD, NCI-C60957, NSC 7778, NSC-7778, ONGROSTAB HMB, OXIBENZONA, OXIBENZONUM, OXYBENZON, OXYBENZONE, OXYBENZONE (BENZOPHENONE-3), OXYBENZONE 6, OXYBENZONUM, SOLAQUIN, SPECTRA-SORB UV 9, SUNSCREEN UV-15, SYNTASE 62, UF 3, USAF CY-9, UV 9, UVINUL 9, UVINUL M40, and UVISTAT 24
Oxybenzone is a sunscreen ingredient associated with photoallergic reactions. This chemical absorbs through the skin in significant amounts. It contaminates the bodies of 97% of Americans according to research by the Centers for Disease Control and Prevention.
See how this product scores for common concerns.
MODERATEAllergies & Immunotoxicity
LOWDevelopmental and Reingredientive Toxicity
- DATA SOURCES
Products with this Ingredient
|recreational sunscreen||127 products|
|daily use with SPF||124 products|
|lip balm with SPF||32 products|
|fragrance for women||30 products|
|nail polish||27 products|
|BB cream||23 products|
|fragrance for men||23 products|
|baby sunscreen||18 products|
|facial moisturizer/treatment||7 products|
|hair treatment/serum||5 products|
|hair styling aide||5 products|
|body wash/cleanser||4 products|
|after shave||4 products|
|hair spray||3 products|
|facial powder||2 products|
|tanning oil||2 products|
|lip balm||2 products|
|setting powder/spray||2 products|
|lip gloss||2 products|
|body spray||2 products|
|nail glue||2 products|
|bath oil/salts/soak||1 products|
|liquid hand soap||1 products|
|nail treatment||1 products|
|makeup primer||1 products|
|damaged skin treatment||1 products|
|hair color and bleaching||1 products|
Enhanced skin absorption
|Penetration enhancer||Open scientific literature|
|Absorbs into the skin||Open scientific literature|
Biochemical or cellular level changes
|Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.||Open scientific literature|
|Does not produces excess reactive oxygen species or other harmful biochemical changes.||Open scientific literature|
|Possible human photoallergenic toxicant or allergen||Open scientific literature|
|One or more human case studies show significant photoallergenic or allergenic effects||Open scientific literature|
|One or more human case studies show possible Photoallergic or allergenic effects||Open scientific literature|
|Limited evidence of immune system (sensitization) toxicity or allergies||Open scientific literature|
|Not likely to be a immune system toxicant or allergenic in humans||Open scientific literature|
|Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)||Japan's Standards for Cosmetics|
|Human endocrine disruptor - moderate evidence||European Commission on Endocrine Disruption|
|Limited evidence of wildlife and the environment disruption||European Commission on Endocrine Disruption|
|One or more studies show weak endocrine disruption||Open scientific literature|
|Associated with endocrine disruption||Open scientific literature|
Persistence and bioaccumulation
|Ingredient is suspected or measured to accumulate in people||Open scientific literature|
|Not suspected to be bioaccumulative||Environment Canada Domestic Substance List|
|Limited evidence of developmental toxicity||Open scientific literature|
|One or more animal studies show developmental effects at high doses||Open scientific literature|
Organ system toxicity (non-reproductive)
|One or more animal studies show cardiovascular effects at moderate doses (low dose studies may be unavailable for this ingredient)||Open scientific literature|
|Classified as not expected to be potentially toxic or harmful||Environment Canada Domestic Substance List|
|One or more animal studies show no adverse broad systemic effects at high doses||Open scientific literature|
|Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product||Cosmetic Ingredient Review Assessments|
|10524 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
|Wildlife and environmental toxicity||Open scientific literature|
|Not suspected to be an environmental toxin||Environment Canada Domestic Substance List|
|Not likely to be mutagenic in humans||Open scientific literature|
|Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any||Cosmetic Ingredient Review Assessments|
Irritation (skin, eyes, or lungs)
|Not likely to be a any irritant in humans||Open scientific literature|
- Open scientific/peer reviewed literature
- Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
- EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.
Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.HOW WE DETERMINE SCORES
The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.
The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.