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OXYBENZONE

Score:

Data: Good

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Use restrictions (moderate), Endocrine disruption (moderate), Persistence and bioaccumulation (low), Non-reproductive organ system toxicity (low), and Biochemical or cellular level changes (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is MODERATE

Products with this Ingredient

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recreational sunscreen196 products
daily use with SPF149 products
lip balm with SPF41 products
baby sunscreen29 products
BB cream27 products
nail polish25 products
fragrance for men20 products
foundation14 products
fragrance for women13 products
concealer8 products
hair treatment/serum6 products
exfoliant/scrub6 products
hair styling aide6 products
facial moisturizer/treatment5 products
moisturizer4 products
after shave4 products
lip balm4 products
body wash/cleanser4 products
bronzer/highlighter3 products
3 products
conditioner3 products
hair spray3 products
setting powder/spray2 products
facial powder2 products
lip gloss2 products
body spray2 products
tanning oil2 products
bath oil/salts/soak2 products
body oil1 products
detangler1 products
facial cleanser1 products
body firming lotion1 products
shaving cream1 products
styling gel/lotion1 products
anti-aging1 products
shampoo1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancerOpen scientific literature
Absorbs into the skinOpen scientific literature

Biochemical or cellular level changes

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Concern Reference
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.Open scientific literature
Does not produces excess reactive oxygen species or other harmful biochemical changes.Open scientific literature

Allergies/immunotoxicity

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Concern Reference
Possible human photoallergenic toxicant or allergenOpen scientific literature
One or more human case studies show significant photoallergenic or allergenic effectsOpen scientific literature
One or more human case studies show possible Photoallergic or allergenic effectsOpen scientific literature
Limited evidence of immune system (sensitization) toxicity or allergiesOpen scientific literature
Not likely to be a immune system toxicant or allergenic in humansOpen scientific literature

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics

Endocrine disruption

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Concern Reference
Human endocrine disruptor - moderate evidenceEuropean Commission on Endocrine Disruption
Limited evidence of wildlife and the environment disruptionEuropean Commission on Endocrine Disruption
One or more studies show weak endocrine disruptionOpen scientific literature
Associated with endocrine disruptionOpen scientific literature

Persistence and bioaccumulation

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Concern Reference
Ingredient is suspected or measured to accumulate in peopleOpen scientific literature
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Developmental/reproductive toxicity

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Concern Reference
Limited evidence of developmental toxicityOpen scientific literature
One or more animal studies show developmental effects at high dosesOpen scientific literature

Organ system toxicity (non-reproductive)

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Concern Reference
One or more animal studies show cardiovascular effects at moderate doses (low dose studies may be unavailable for this ingredient)Open scientific literature
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
One or more animal studies show no adverse broad systemic effects at high dosesOpen scientific literature

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
10524 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityOpen scientific literature
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Cancer

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Concern Reference
Not likely to be mutagenic in humansOpen scientific literature

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Irritation (skin, eyes, or lungs)

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Concern Reference
Not likely to be a any irritant in humansOpen scientific literature

Data Sources

  • Open scientific/peer reviewed literature
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

ABOUT THE SKIN DEEP® RATINGS

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