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OCTISALATE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption and Use restrictions (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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recreational sunscreen557 products
daily use with SPF320 products
baby sunscreen76 products
fragrance for women76 products
fragrance for men52 products
lip balm with SPF38 products
body spray34 products
BB cream27 products
foundation20 products
facial moisturizer/treatment18 products
CC cream13 products
hair treatment/serum11 products
body wash/cleanser10 products
tanning oil8 products
hair color and bleaching6 products
makeup primer6 products
after shave6 products
conditioner6 products
facial cleanser5 products
hand sanitizer4 products
moisturizer4 products
hair styling aide4 products
shampoo3 products
sunless tanning3 products
3 products
anti-aging3 products
setting powder/spray3 products
serums & essences2 products
toners/astringents2 products
body firming lotion2 products
styling mousse/foam2 products
skin fading/lightener1 products
mask1 products
styling gel/lotion1 products
hair spray1 products
lip balm1 products
oil controller1 products
bar soap1 products
other eye makeup1 products

Enhanced skin absorption

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Concern Reference
Increased penetration amount and decreased lag time of 2,4-D in human volunteers{Pont, 2004}
Absorbs and permeates into the skinWalters KA, Brain KR, Howes D, James VJ, Kraus AL, Teetsel NM, et al 1997. Percutaneous penetration of octyl salicylate from representative sunscreen formulations through human skin in vitro. Food Chem Toxicol 35(12): 1219-1225.

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Allergies/immunotoxicity

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Concern Reference
Case study report of allergy to octisalateShaw DW 2006. Allergic contact dermatitis from octisalate and cis-3-hexenyl salicylate. Dermatitis 17(3): 152-155.

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Biochemical or cellular level changes

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Concern Reference
Does not produce damaging reactive oxygen species upon exposure to sunlight{Allen, 1996}

Data gaps

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Concern Reference
2123 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • {Pont, 2004}
  • Walters KA, Brain KR, Howes D, James VJ, Kraus AL, Teetsel NM, et al 1997. Percutaneous penetration of octyl salicylate from representative sunscreen formulations through human skin in vitro. Food Chem Toxicol 35(12): 1219-1225.
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • Shaw DW 2006. Allergic contact dermatitis from octisalate and cis-3-hexenyl salicylate. Dermatitis 17(3): 152-155.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • {Allen, 1996}
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About this Ingredient's Score Range

  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

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