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OCTISALATE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption and Use restrictions (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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beach & sport sunscreen402 products
moisturizer with SPF226 products
lip balm with SPF34 products
baby sunscreen20 products
BB cream16 products
fragrance for women15 products
fragrance for men7 products
CC cream3 products
makeup with SPF3 products
after shave2 products
facial moisturizer/treatment1 products
foundation1 products
tanning oil1 products
hair color and bleaching1 products
concealer1 products
other eye makeup1 products
hair treatment/serum1 products
hair styling aide1 products
lip balm1 products
facial cleanser1 products
body wash/cleanser1 products
serums & essences1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancer{Pont, 2004}
Absorbs into the skinWalters KA, Brain KR, Howes D, James VJ, Kraus AL, Teetsel NM, et al 1997. Percutaneous penetration of octyl salicylate from representative sunscreen formulations through human skin in vitro. Food Chem Toxicol 35(12): 1219-1225.

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Allergies/immunotoxicity

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Concern Reference
One or more human case studies show possible immune or allergenic effectsShaw DW 2006. Allergic contact dermatitis from octisalate and cis-3-hexenyl salicylate. Dermatitis 17(3): 152-155.

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Biochemical or cellular level changes

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Concern Reference
Does not produces excess reactive oxygen species or other harmful biochemical changes.{Allen, 1996}

Data gaps

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Concern Reference
2123 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • {Pont, 2004}
  • Walters KA, Brain KR, Howes D, James VJ, Kraus AL, Teetsel NM, et al 1997. Percutaneous penetration of octyl salicylate from representative sunscreen formulations through human skin in vitro. Food Chem Toxicol 35(12): 1219-1225.
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • Shaw DW 2006. Allergic contact dermatitis from octisalate and cis-3-hexenyl salicylate. Dermatitis 17(3): 152-155.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • {Allen, 1996}
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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