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OCTINOXATE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Endocrine disruption (moderate), Persistence and bioaccumulation (low), Non-reproductive organ system toxicity (low), and Biochemical or cellular level changes (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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moisturizer with SPF181 products
lip balm with SPF83 products
fragrance for women77 products
lipstick66 products
fragrance for men52 products
beach & sport sunscreen51 products
foundation34 products
hair spray32 products
BB cream30 products
shampoo21 products
conditioner17 products
facial powder16 products
body wash/cleanser15 products
moisturizer15 products
concealer12 products
facial moisturizer/treatment12 products
hair treatment/serum11 products
makeup primer8 products
bronzer/highlighter8 products
blush8 products
lip gloss7 products
body spray6 products
lip balm5 products
CC cream5 products
styling gel/lotion4 products
body oil4 products
hair styling aide4 products
serums & essences4 products
lip plumper3 products
liquid hand soap3 products
baby sunscreen3 products
anti-aging2 products
2 products
hand cream2 products
makeup with SPF2 products
exfoliant/scrub2 products
after shave1 products
styling mousse/foam1 products
nail polish1 products
hair relaxer1 products
toners/astringents1 products
detangler1 products
eye makeup remover1 products
beard care1 products
facial cleanser1 products
other eye makeup1 products

Enhanced skin absorption

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Concern Reference
OMC increased penetration of 2,4D (a pesticide) and decreased lag time.Pont AR, Charron AR, Brand RM 2004. Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. Toxicol Appl Pharmacol 195(3): 348-354.
Is absorbed into skin in vitro at 0 to X%{Gupta, 1999; Potard, 2000; Benech-Kieffer, 2000}

Biochemical or cellular level changes

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Concern Reference
Produces damaging reactive oxygen species upon exposure to sunlight{Allen, 1996}

Endocrine disruption

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Concern Reference
Human endocrine disruptor - strong evidenceEuropean Commission on Endocrine Disruption
One or more studies show significant wildlife and the environment disruptionEuropean Commission on Endocrine Disruption
Octyl-Methoxycinnamate could alter the sex hormone/neurotransmitter relationships in rats.Carbone 2010. In Vitro Effect of Octyl - Methoxycinnamate (OMC) on the Release of Gn-RH and Amino Acid Neurotransmitters by Hypothalamus of Adult Rats. Exp Clin Endocrinol Diabetes.
Octylmethoxycinnamate decreased the hormonal release significantly in male and female rats , potentially affecting the reproductive system and sexual maturation.Szwarcfarb B, Carbone S, Reynoso R, Bollero G, Ponzo O, Moguilevsky J, Scacchi P "Octyl-methoxycinnamate (OMC), an ultraviolet (UV) filter, alters LHRH and amino acid neurotransmitters release from hypothalamus of immature rats." Exp Clin Endocrinol Diabetes. 2008 Feb;116(2):94-8.
Octyl-methoxycinnamate decreased serum levels of thyroid hormones TSH, T4 and T3 in female rats.Klammer H, Schlecht C, Wuttke W, Schmutzler C, Gotthardt I, Köhrle J, Jarry H "Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats." Toxicology. 2007 Sep 5;238(2-3):192-9.

Allergies/immunotoxicity

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Concern Reference
8 of 82 patients diagnosed with photoallergic contact dermatitis displayed photoallergic reactions to octyl methoxycinnamate following a photopatch test.Rodriguez E, Valbuena MC, Rey M, Porras de Quintana L 2006. Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. Photodermatol Photoimmunol Photomed 22(4): 189-192.

Persistence and bioaccumulation

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Concern Reference
In the men the plasma concentrations of OMC were significantly higher after 96 h than after 24 h.Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, et al 2004. Systemic Absorption of the Sunscreens Benzophenone-3, Octyl-Methoxycinnamate, and 3-(4-Methyl-Benzylidene) Camphor after Whole-Body Topical Application and Reproductive Hormone Levels in Humans. Journal of Investigative Dermatology 123(1): 57-61.
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Developmental/reproductive toxicity

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Concern Reference
Increased uterine weight at dose of 100 mg/kg in rats; in addition, expression of Erb and TERP1 genes, decreased expression of IGF1 gene, decreased cholesterol and LDL levelsKlammer 2005. Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo A 5-day sub-acute pharmacodynamic study with ovariectomized rats. Toxicology. Nov 5;215(1-2):90-6
Led to reduced food consumption and body weight, increased liver weight, produced hepatic cytoplasmic eosinophilia and erosion/ulceration of glandular stomach mucosa, decreased implantation rate and delayed maturation of F1 and F2 pupsSchneider 2005. Octyl methoxycinnamate: two generation reproduction toxicity in Wistar rats by dietary administration. Food Chem Toxicol. 43(7):1083-92.

Organ system toxicity (non-reproductive)

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Concern Reference
2-generation rat study shows increased liver weight in adults fed 1000 mg/kg OMC.Schneider "Octyl methoxycinnamate: two generation reproduction toxicity in Wistar rats by dietary administration" Food Chem Toxicol. 2005 Jul;43(7):1083-92.
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Ecotoxicology

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Concern Reference
Concentrations in water and fish from Swiss LakesME. Balmer, H.R. Buser, M.D. Muller, T. Poiger. 2004. Occurrence of the organic UV-filter compounds BP-3, 4-MBC, EHMC, and OC in wastewater, surface waters, and in fish from Swiss lakes, Agroscope, Swiss Federal Research Station for Horticulture, Plant Protection Chemistry, CH-8820W’’Adenswil, Switzerland.
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
799 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • Pont AR, Charron AR, Brand RM 2004. Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. Toxicol Appl Pharmacol 195(3): 348-354.
  • {Gupta, 1999; Potard, 2000; Benech-Kieffer, 2000}
  • {Allen, 1996}
  • EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
  • Carbone 2010. In Vitro Effect of Octyl - Methoxycinnamate (OMC) on the Release of Gn-RH and Amino Acid Neurotransmitters by Hypothalamus of Adult Rats. Exp Clin Endocrinol Diabetes.
  • Szwarcfarb B, Carbone S, Reynoso R, Bollero G, Ponzo O, Moguilevsky J, Scacchi P "Octyl-methoxycinnamate (OMC), an ultraviolet (UV) filter, alters LHRH and amino acid neurotransmitters release from hypothalamus of immature rats." Exp Clin Endocrinol Diabetes. 2008 Feb;116(2):94-8.
  • Klammer H, Schlecht C, Wuttke W, Schmutzler C, Gotthardt I, Köhrle J, Jarry H "Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats." Toxicology. 2007 Sep 5;238(2-3):192-9.
  • Rodriguez E, Valbuena MC, Rey M, Porras de Quintana L 2006. Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. Photodermatol Photoimmunol Photomed 22(4): 189-192.
  • Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, et al 2004. Systemic Absorption of the Sunscreens Benzophenone-3, Octyl-Methoxycinnamate, and 3-(4-Methyl-Benzylidene) Camphor after Whole-Body Topical Application and Reproductive Hormone Levels in Humans. Journal of Investigative Dermatology 123(1): 57-61.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Klammer 2005. Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo A 5-day sub-acute pharmacodynamic study with ovariectomized rats. Toxicology. Nov 5;215(1-2):90-6
  • Schneider 2005. Octyl methoxycinnamate: two generation reproduction toxicity in Wistar rats by dietary administration. Food Chem Toxicol. 43(7):1083-92.
  • Schneider "Octyl methoxycinnamate: two generation reproduction toxicity in Wistar rats by dietary administration" Food Chem Toxicol. 2005 Jul;43(7):1083-92.
  • ME. Balmer, H.R. Buser, M.D. Muller, T. Poiger. 2004. Occurrence of the organic UV-filter compounds BP-3, 4-MBC, EHMC, and OC in wastewater, surface waters, and in fish from Swiss lakes, Agroscope, Swiss Federal Research Station for Horticulture, Plant Protection Chemistry, CH-8820W’’Adenswil, Switzerland.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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