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OCTINOXATE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Endocrine disruption (moderate), Persistence and bioaccumulation (low), Non-reproductive organ system toxicity (low), and Biochemical or cellular level changes (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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moisturizer with SPF200 products
lip balm with SPF83 products
beach & sport sunscreen81 products
lipstick62 products
fragrance for women20 products
BB cream20 products
facial powder15 products
fragrance for men9 products
foundation7 products
bronzer/highlighter7 products
baby sunscreen6 products
blush6 products
moisturizer6 products
CC cream6 products
lip gloss4 products
concealer4 products
serums & essences3 products
hair spray3 products
lip balm3 products
lip plumper3 products
conditioner2 products
exfoliant/scrub2 products
makeup primer2 products
facial moisturizer/treatment1 products
styling gel/lotion1 products
skin fading/lightener1 products
facial cleanser1 products
other eye makeup1 products
shampoo1 products
tanning oil1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancerPont AR, Charron AR, Brand RM 2004. Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. Toxicol Appl Pharmacol 195(3): 348-354.
Absorbs into the skin{Gupta, 1999; Potard, 2000; Benech-Kieffer, 2000}

Biochemical or cellular level changes

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Concern Reference
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.{Allen, 1996}

Endocrine disruption

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Concern Reference
Human endocrine disruptor - strong evidenceEuropean Commission on Endocrine Disruption
One or more studies show significant wildlife and the environment disruptionEuropean Commission on Endocrine Disruption
One or more studies show moderate endocrine disruptionCarbone 2010. In Vitro Effect of Octyl - Methoxycinnamate (OMC) on the Release of Gn-RH and Amino Acid Neurotransmitters by Hypothalamus of Adult Rats. Exp Clin Endocrinol Diabetes.
One or more studies show weak endocrine disruptionSzwarcfarb B, Carbone S, Reynoso R, Bollero G, Ponzo O, Moguilevsky J, Scacchi P "Octyl-methoxycinnamate (OMC), an ultraviolet (UV) filter, alters LHRH and amino acid neurotransmitters release from hypothalamus of immature rats." Exp Clin Endocrinol Diabetes. 2008 Feb;116(2):94-8.
Associated with endocrine disruptionKlammer H, Schlecht C, Wuttke W, Schmutzler C, Gotthardt I, Köhrle J, Jarry H "Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats." Toxicology. 2007 Sep 5;238(2-3):192-9.

Allergies/immunotoxicity

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Concern Reference
One or more human case studies show possible photoallergic or allergenic effectsRodriguez E, Valbuena MC, Rey M, Porras de Quintana L 2006. Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. Photodermatol Photoimmunol Photomed 22(4): 189-192.

Persistence and bioaccumulation

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Concern Reference
Ingredient is suspected or measured to accumulate in peopleJanjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, et al 2004. Systemic Absorption of the Sunscreens Benzophenone-3, Octyl-Methoxycinnamate, and 3-(4-Methyl-Benzylidene) Camphor after Whole-Body Topical Application and Reproductive Hormone Levels in Humans. Journal of Investigative Dermatology 123(1): 57-61.
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Developmental/reproductive toxicity

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Concern Reference
One or more animal studies show reproductive effects at moderate dosesKlammer 2005. Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo A 5-day sub-acute pharmacodynamic study with ovariectomized rats. Toxicology. Nov 5;215(1-2):90-6
One or more animal studies show developmental effects at high dosesSchneider 2005. Octyl methoxycinnamate: two generation reproduction toxicity in Wistar rats by dietary administration. Food Chem Toxicol. 43(7):1083-92.

Organ system toxicity (non-reproductive)

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Concern Reference
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)Schneider "Octyl methoxycinnamate: two generation reproduction toxicity in Wistar rats by dietary administration" Food Chem Toxicol. 2005 Jul;43(7):1083-92.
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityME. Balmer, H.R. Buser, M.D. Muller, T. Poiger. 2004. Occurrence of the organic UV-filter compounds BP-3, 4-MBC, EHMC, and OC in wastewater, surface waters, and in fish from Swiss lakes, Agroscope, Swiss Federal Research Station for Horticulture, Plant Protection Chemistry, CH-8820W’’Adenswil, Switzerland.
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
799 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • Pont AR, Charron AR, Brand RM 2004. Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. Toxicol Appl Pharmacol 195(3): 348-354.
  • {Gupta, 1999; Potard, 2000; Benech-Kieffer, 2000}
  • {Allen, 1996}
  • EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
  • Carbone 2010. In Vitro Effect of Octyl - Methoxycinnamate (OMC) on the Release of Gn-RH and Amino Acid Neurotransmitters by Hypothalamus of Adult Rats. Exp Clin Endocrinol Diabetes.
  • Szwarcfarb B, Carbone S, Reynoso R, Bollero G, Ponzo O, Moguilevsky J, Scacchi P "Octyl-methoxycinnamate (OMC), an ultraviolet (UV) filter, alters LHRH and amino acid neurotransmitters release from hypothalamus of immature rats." Exp Clin Endocrinol Diabetes. 2008 Feb;116(2):94-8.
  • Klammer H, Schlecht C, Wuttke W, Schmutzler C, Gotthardt I, Köhrle J, Jarry H "Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats." Toxicology. 2007 Sep 5;238(2-3):192-9.
  • Rodriguez E, Valbuena MC, Rey M, Porras de Quintana L 2006. Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. Photodermatol Photoimmunol Photomed 22(4): 189-192.
  • Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, et al 2004. Systemic Absorption of the Sunscreens Benzophenone-3, Octyl-Methoxycinnamate, and 3-(4-Methyl-Benzylidene) Camphor after Whole-Body Topical Application and Reproductive Hormone Levels in Humans. Journal of Investigative Dermatology 123(1): 57-61.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Klammer 2005. Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo A 5-day sub-acute pharmacodynamic study with ovariectomized rats. Toxicology. Nov 5;215(1-2):90-6
  • Schneider 2005. Octyl methoxycinnamate: two generation reproduction toxicity in Wistar rats by dietary administration. Food Chem Toxicol. 43(7):1083-92.
  • Schneider "Octyl methoxycinnamate: two generation reproduction toxicity in Wistar rats by dietary administration" Food Chem Toxicol. 2005 Jul;43(7):1083-92.
  • ME. Balmer, H.R. Buser, M.D. Muller, T. Poiger. 2004. Occurrence of the organic UV-filter compounds BP-3, 4-MBC, EHMC, and OC in wastewater, surface waters, and in fish from Swiss lakes, Agroscope, Swiss Federal Research Station for Horticulture, Plant Protection Chemistry, CH-8820W’’Adenswil, Switzerland.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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