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OCTINOXATE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Endocrine disruption (moderate), Persistence and bioaccumulation (low), Non-reproductive organ system toxicity (low), and Biochemical or cellular level changes (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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daily use with SPF274 products
foundation143 products
fragrance for women117 products
lip balm with SPF112 products
lipstick93 products
fragrance for men78 products
hair spray70 products
recreational sunscreen68 products
shampoo47 products
conditioner46 products
BB cream43 products
body spray29 products
hair treatment/serum27 products
concealer23 products
facial powder22 products
CC cream20 products
moisturizer16 products
makeup primer15 products
body wash/cleanser15 products
facial moisturizer/treatment15 products
anti-aging12 products
12 products
lip balm11 products
hair styling aide11 products
baby sunscreen9 products
blush8 products
styling gel/lotion7 products
bronzer/highlighter7 products
lip gloss7 products
serums & essences6 products
styling mousse/foam5 products
after shave5 products
hand cream4 products
body oil4 products
facial cleanser4 products
exfoliant/scrub3 products
liquid hand soap3 products
lip plumper3 products
detangler2 products
setting powder/spray2 products
skin fading/lightener2 products
toners/astringents1 products
tanning oil1 products
hair color and bleaching1 products
sunless tanning1 products
eye makeup remover1 products
other eye makeup1 products
hand sanitizer1 products
nail polish1 products
bar soap1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancerOpen scientific literature
Absorbs into the skinOpen scientific literature

Biochemical or cellular level changes

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Concern Reference
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.Open scientific literature

Endocrine disruption

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Concern Reference
Human endocrine disruptor - strong evidenceEuropean Commission on Endocrine Disruption
One or more studies show significant wildlife and the environment disruptionEuropean Commission on Endocrine Disruption
One or more studies show moderate endocrine disruptionOpen scientific literature
One or more studies show weak endocrine disruptionOpen scientific literature
Associated with endocrine disruptionOpen scientific literature

Allergies/immunotoxicity

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Concern Reference
One or more human case studies show possible photoallergic or allergenic effectsOpen scientific literature

Persistence and bioaccumulation

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Concern Reference
Ingredient is suspected or measured to accumulate in peopleOpen scientific literature
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List
Not suspected to be persistentEnvironment Canada Domestic Substance List

Developmental/reproductive toxicity

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Concern Reference
One or more animal studies show reproductive effects at moderate dosesOpen scientific literature
One or more animal studies show reproductive effects at high dosesOpen scientific literature

Organ system toxicity (non-reproductive)

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Concern Reference
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)Open scientific literature
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityOpen scientific literature
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
799 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • Open scientific/peer reviewed literature
  • EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

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