Menu Close Menu

Menu

METHYLISOTHIAZOLINONE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Neurotoxicity (low), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

Expand content Collapse content
shampoo99 products
conditioner79 products
body wash/cleanser73 products
liquid hand soap59 products
beach & sport sunscreen44 products
hair color and bleaching32 products
facial cleanser11 products
moisturizer with SPF8 products
bath oil/salts/soak6 products
styling gel/lotion5 products
mask5 products
hair styling aide5 products
moisturizer4 products
bubble bath4 products
exfoliant/scrub3 products
mascara3 products
detangler3 products
bronzer/highlighter2 products
hair treatment/serum2 products
shaving cream2 products
facial moisturizer/treatment2 products
baby shampoo1 products
body powder1 products
body spray1 products
blush1 products
makeup primer1 products
serums & essences1 products
after shave1 products
BB cream1 products

Allergies/immunotoxicity

Expand content Collapse content
Concern Reference
Known human immune toxicant or allergenEuropean SCCS 2014. SCCS Opinion on Methylisothiazolinone (P94) Submission II (Sensitisation only). European Scientific Committee on Consumer Safety. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_145.pdf
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Human sensitizer toxicant or allergen - strong evidenceBurnett CL, Bergfeld WF, et al 2010. Final report of the safety assessment of methylisothiazolinone. Int J Toxicol. 29(4 Suppl):187S-213S.
Human any toxicant or allergen - moderate evidenceM D Lundov, T Krongaard, T L Menné & J D Johansen 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
One or more human case studies show significant skin or allergenic effectsChang MW, Nakrani R 2014. Six children with allergic contact dermatitis to methylisothiazolinone in wet wipes (baby wipes). Pediatrics. 133(2):e434-8.
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Use restrictions

Expand content Collapse content
Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Violation of government restrictions - Banned or found unsafe for use in cosmeticsEuropean SCCS 2014. SCCS Opinion on Methylisothiazolinone (P94) Submission II (Sensitisation only). European Scientific Committee on Consumer Safety. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_145.pdf
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - concentration limit in some types of cosmetics when combined with certain other ingredient(s)Japan's Standards for Cosmetics
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Irritation (skin, eyes, or lungs)

Expand content Collapse content
Concern Reference
Possible human skin sensitizer irritantNIOSH (Cook CK, Friedman D) 1996. Health Hazard Evaluation Report, HEA 94–0402–2573. National Institute for Occupational Health and Safety.

Neurotoxicity

Expand content Collapse content
Concern Reference
One or more in vitro tests on mammalian cells demonstrate neurotoxicityDu S, McLaughlin BA, Pal S, AizenmanIn E 2002. In Vitro Neurotoxicity of Methylisothiazolinone, a Commonly Used Industrial and Household Biocide, Proceeds via a Zinc and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent Pathway. The Journal of Neuroscience, September 1, 2002, 22(17):7408-7416.

Ecotoxicology

Expand content Collapse content
Concern Reference
Wildlife and environmental toxicityUS. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

Expand content Collapse content
Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
331 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Organ system toxicity (non-reproductive)

Expand content Collapse content
Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

Expand content Collapse content
Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • European SCCS 2014. SCCS Opinion on Methylisothiazolinone (P94) Submission II (Sensitisation only). European Scientific Committee on Consumer Safety. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_145.pdf
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • Burnett CL, Bergfeld WF, et al 2010. Final report of the safety assessment of methylisothiazolinone. Int J Toxicol. 29(4 Suppl):187S-213S.
  • M D Lundov, T Krongaard, T L Menné & J D Johansen 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
  • Chang MW, Nakrani R 2014. Six children with allergic contact dermatitis to methylisothiazolinone in wet wipes (baby wipes). Pediatrics. 133(2):e434-8.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • NIOSH (Cook CK, Friedman D) 1996. Health Hazard Evaluation Report, HEA 94–0402–2573. National Institute for Occupational Health and Safety.
  • Du S, McLaughlin BA, Pal S, AizenmanIn E 2002. In Vitro Neurotoxicity of Methylisothiazolinone, a Commonly Used Industrial and Household Biocide, Proceeds via a Zinc and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent Pathway. The Journal of Neuroscience, September 1, 2002, 22(17):7408-7416.
  • US. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer