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METHYLISOTHIAZOLINONE
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high), Neurotoxicity (low), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (moderate)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| shampoo | 591 products |
| conditioner | 541 products |
| body wash/cleanser | 512 products |
| liquid hand soap | 415 products |
| bubble bath | 83 products |
| hair color and bleaching | 81 products |
| facial cleanser | 77 products |
| hair treatment/serum | 71 products |
| mask | 45 products |
| exfoliant/scrub | 40 products |
| hair styling aide | 37 products |
| styling gel/lotion | 26 products |
| moisturizer | 22 products |
| bath oil/salts/soak | 20 products |
| recreational sunscreen | 19 products |
| facial moisturizer/treatment | 12 products |
| baby shampoo | 12 products |
| baby wipes | 10 products |
| baby bubble bath | 10 products |
| daily use with SPF | 9 products |
| hand sanitizer | 7 products |
| baby soap | 6 products |
| foot cleansing | 6 products |
| beard cleanser | 6 products |
| styling mousse/foam | 5 products |
| detangler | 5 products |
| body firming lotion | 5 products |
| bar soap | 5 products |
| serums & essences | 5 products |
| glitter | 5 products |
| mascara | 4 products |
| body spray | 4 products |
| 4 products | |
| anti-aging | 3 products |
| hair spray | 3 products |
| after sun product | 3 products |
| shaving cream | 3 products |
| foot moisturizer | 2 products |
| shaving cream (men's) | 2 products |
| hair relaxer | 2 products |
| eye liner | 2 products |
| foundation | 2 products |
| eye shadow | 2 products |
| makeup remover | 2 products |
| nail polish | 2 products |
| damaged skin treatment | 2 products |
| baby oil | 2 products |
| baby lotion | 2 products |
| beard care | 2 products |
| antiperspirant/deodorant | 1 products |
| around-eye cream | 1 products |
| depilatory | 1 products |
| sunless tanning | 1 products |
| BB cream | 1 products |
| baby sunscreen | 1 products |
| after shave | 1 products |
Use restrictions
| Concern | Reference |
|---|---|
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | Open scientific literature |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - concentration limit in some types of cosmetics when combined with certain other ingredient(s) | Japan's Standards for Cosmetics |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Cosmetic Ingredient Review Assessments |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Known human immune toxicant or allergen | Open scientific literature |
| Human sensitizer toxicant or allergen - strong evidence | Open scientific literature |
| Human skin toxicant or allergen - strong evidence | Cosmetic Ingredient Review Assessments |
| Human any toxicant or allergen - moderate evidence | Open scientific literature |
| One or more human case studies show significant skin or allergenic effects | Open scientific literature |
| Limited evidence of immune system toxicity or allergies | National Library of Medicine HazMap |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Possible human skin sensitizer irritant | Open scientific literature |
Neurotoxicity
| Concern | Reference |
|---|---|
| One or more in vitro tests on mammalian cells demonstrate neurotoxicity | Open scientific literature |
Ecotoxicology
| Concern | Reference |
|---|---|
| Wildlife and environmental toxicity | Open scientific literature |
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern | Reference |
|---|---|
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments |
| 331 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
| Not suspected to be persistent | Environment Canada Domestic Substance List |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Data Sources
- Open scientific/peer reviewed literature
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
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