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METHYLISOTHIAZOLINONE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Neurotoxicity (low), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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shampoo194 products
conditioner159 products
body wash/cleanser148 products
liquid hand soap111 products
hair color and bleaching52 products
beach & sport sunscreen34 products
mask21 products
facial cleanser17 products
bubble bath16 products
moisturizer10 products
exfoliant/scrub10 products
bath oil/salts/soak9 products
moisturizer with SPF8 products
hair styling aide7 products
hair treatment/serum7 products
styling gel/lotion5 products
body firming lotion4 products
body spray4 products
shaving cream3 products
detangler3 products
facial moisturizer/treatment3 products
mascara3 products
Facial Sun Care2 products
foot cleansing2 products
bronzer/highlighter2 products
blush2 products
hand sanitizer1 products
serums & essences1 products
beard cleanser1 products
baby shampoo1 products
styling mousse/foam1 products
makeup with SPF1 products
body powder1 products
makeup primer1 products

Allergies/immunotoxicity

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Concern Reference
The European SCCS has declared that there is no safe concentration of MIT in leave-on products, and that concentrations in rinse-off products must be less than 15 parts per millionEuropean SCCS 2014. SCCS Opinion on Methylisothiazolinone (P94) Submission II (Sensitisation only). European Scientific Committee on Consumer Safety. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_145.pdf
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Skin sensitizer - can instigate immune system response that can include itching, burning, scaling, hives, and blistering of skinBurnett CL, Bergfeld WF, et al 2010. Final report of the safety assessment of methylisothiazolinone. Int J Toxicol. 29(4 Suppl):187S-213S.
A review article reports that this substance causes contact allergies.M D Lundov, T Krongaard, T L Menné & J D Johansen 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
A case report finds 6 American children using wet wipes with MIT tested positive for MCI/MIT skin allergy.Chang MW, Nakrani R 2014. Six children with allergic contact dermatitis to methylisothiazolinone in wet wipes (baby wipes). Pediatrics. 133(2):e434-8.
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Use restrictions

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Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
The European SCCS has declared that there is no safe concentration of MIT in leave-on products, and that concentrations in rinse-off products must be less than 15 parts per millionEuropean SCCS 2014. SCCS Opinion on Methylisothiazolinone (P94) Submission II (Sensitisation only). European Scientific Committee on Consumer Safety. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_145.pdf
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - concentration limit in some types of cosmetics when combined with certain other ingredient(s)Japan's Standards for Cosmetics
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Irritation (skin, eyes, or lungs)

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Concern Reference
NIOSH reports that this substance is a skin irritant.NIOSH (Cook CK, Friedman D) 1996. Health Hazard Evaluation Report, HEA 94–0402–2573. National Institute for Occupational Health and Safety.

Neurotoxicity

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Concern Reference
In-vitro study demonstrates this common biocide is highly toxic to neurons.Du S, McLaughlin BA, Pal S, AizenmanIn E 2002. In Vitro Neurotoxicity of Methylisothiazolinone, a Commonly Used Industrial and Household Biocide, Proceeds via a Zinc and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent Pathway. The Journal of Neuroscience, September 1, 2002, 22(17):7408-7416.

Ecotoxicology

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Concern Reference
The US EPA reports the LC50 value is very toxic to aquatic life.US. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
331 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • European SCCS 2014. SCCS Opinion on Methylisothiazolinone (P94) Submission II (Sensitisation only). European Scientific Committee on Consumer Safety. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_145.pdf
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • Burnett CL, Bergfeld WF, et al 2010. Final report of the safety assessment of methylisothiazolinone. Int J Toxicol. 29(4 Suppl):187S-213S.
  • M D Lundov, T Krongaard, T L Menné & J D Johansen 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
  • Chang MW, Nakrani R 2014. Six children with allergic contact dermatitis to methylisothiazolinone in wet wipes (baby wipes). Pediatrics. 133(2):e434-8.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • NIOSH (Cook CK, Friedman D) 1996. Health Hazard Evaluation Report, HEA 94–0402–2573. National Institute for Occupational Health and Safety.
  • Du S, McLaughlin BA, Pal S, AizenmanIn E 2002. In Vitro Neurotoxicity of Methylisothiazolinone, a Commonly Used Industrial and Household Biocide, Proceeds via a Zinc and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent Pathway. The Journal of Neuroscience, September 1, 2002, 22(17):7408-7416.
  • US. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About this Ingredient's Score Range

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