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METHYLCHLOROISOTHIAZOLINONE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is MODERATE

Products with this Ingredient

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shampoo573 products
conditioner535 products
body wash/cleanser476 products
liquid hand soap398 products
bubble bath85 products
hair color and bleaching83 products
facial cleanser54 products
hair treatment/serum54 products
mask38 products
bath oil/salts/soak20 products
exfoliant/scrub19 products
hair styling aide18 products
styling gel/lotion13 products
baby shampoo10 products
baby bubble bath10 products
moisturizer9 products
baby wipes7 products
baby soap6 products
beard cleanser6 products
hand sanitizer5 products
4 products
bar soap4 products
detangler3 products
shaving cream2 products
makeup remover2 products
hair relaxer2 products
baby oil2 products
baby lotion2 products
after sun product2 products
body firming lotion2 products
styling mousse/foam2 products
beard care2 products
foot moisturizer1 products
eye liner1 products
foot cleansing1 products
damaged skin treatment1 products
anti-aging1 products
sunless tanning1 products
hair spray1 products
depilatory1 products
mascara1 products

Use restrictions

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Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - anyOpen scientific literature
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics when combined with certain other ingredientsJapan's Standards for Cosmetics
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Irritation (skin, eyes, or lungs)

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Concern Reference
Possible human skin irritantOpen scientific literature

Allergies/immunotoxicity

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Concern Reference
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Human skin toxicant or allergen - moderate evidenceOpen scientific literature
One or more human case studies show significant skin or allergenic effectsOpen scientific literature
Limited evidence of immune system toxicity or allergiesScorecard.org Toxicity Information
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Cancer

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Concern Reference
Mutagen - limited evidenceOpen scientific literature

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityOpen scientific literature
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
232 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • Open scientific/peer reviewed literature
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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