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MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), and Irritation (skin, eyes, or lungs) (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW_MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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facial cleanser56 products
moisturizer53 products
shampoo48 products
conditioner46 products
toothpaste44 products
facial moisturizer/treatment40 products
mask33 products
antiperspirant/deodorant31 products
toners/astringents26 products
beach & sport sunscreen23 products
serums & essences22 products
hair treatment/serum20 products
foundation19 products
exfoliant/scrub17 products
bar soap16 products
body wash/cleanser16 products
foot moisturizer16 products
mouthwash16 products
liquid hand soap8 products
after shave7 products
beard oil7 products
diaper cream6 products
beard care6 products
body oil5 products
makeup primer5 products
hand sanitizer5 products
foot cleansing4 products
makeup remover4 products
lip balm4 products
moisturizer with SPF4 products
lip gloss4 products
shaving cream3 products
hair styling aide3 products
bath oil/salts/soak3 products
muscle/joint soreness3 products
hand cream3 products
sunless tanning2 products
around-eye cream2 products
after sun product2 products
antiperspirant/deodorant (men's)2 products
baby sunscreen2 products
2 products
beard cleanser2 products
pore strips2 products
baby lotion2 products
baby soap2 products
detangler2 products
hair-loss treatment2 products
body spray2 products
vapor rubs1 products
facial powder1 products
lip balm with SPF1 products
eye shadow1 products
shaving cream (men's)1 products
tooth whitening1 products
nail treatment1 products
hair spray1 products
fragrance for men1 products
hair relaxer1 products
damaged skin treatment1 products
baby bubble bath1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancer - alters skin structure, allows other chemicals to penetrate deeper into the skin.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL; ; CAS: 68647-73-4; Classification: PE; R+; D+; S; IR; Notes1: Assessment incomplete -- Scientific Literature Review for Public Comment released 4 Aug 2020

Allergies/immunotoxicity

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Concern Reference
SCCP concludes this substance is a sensitizer in humans.European Commission, Scientific Committee on Consumer Products (SCCP) 2008. Opinion on Tea tree oil. SCCP/1155/08.
tea tree oil linked to sensitization (allergic reactions) in a number of case studiesPirker C et al 2003. Sensitization to tea tree oil in Germany and Austria. A multicenter study of the German Contact Dermatitis Group. J Dtsch Dermatol Ges. 2003 Aug;1(8):629-34.
May cause an allergic skin reaction. European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Melaleuca alternifolia, ext.; -; Essential oil extract of Melaleuca alternifolia (Myrtaceae) leaf; Essential oil obtained from the leaves and terminal branchlets of Melaleuca alternifolia, by steam distillation; Essential oil of Melaleuca alternifolia; cas_numbers: 68647-73-4, 85085-48-9

Irritation (skin, eyes, or lungs)

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Concern Reference
SCCP concludes this substance can cause skin irriration.European Commission, Scientific Committee on Consumer Products (SCCP) 2008. Opinion on Tea tree oil. SCCP/1155/08.
Eye irritation potential reported from animal and in vitro testing.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL; ; CAS: 68647-73-4; Classification: PE; R+; D+; S; IR; Notes1: Assessment incomplete -- Scientific Literature Review for Public Comment released 4 Aug 2020
Causes skin irritation.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Melaleuca alternifolia, ext.; -; Essential oil extract of Melaleuca alternifolia (Myrtaceae) leaf; Essential oil obtained from the leaves and terminal branchlets of Melaleuca alternifolia, by steam distillation; Essential oil of Melaleuca alternifolia; cas_numbers: 68647-73-4, 85085-48-9

Organ system toxicity (non-reproductive)

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Concern Reference
Acute intoxication following ingestion has been reported in humans.European Commission, Scientific Committee on Consumer Products (SCCP) 2008. Opinion on Tea tree oil. SCCP/1155/08.
May be fatal if swallowed and enters airways, is harmful if swallowed, and is harmful if inhaled.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Melaleuca alternifolia, ext.; -; Essential oil extract of Melaleuca alternifolia (Myrtaceae) leaf; Essential oil obtained from the leaves and terminal branchlets of Melaleuca alternifolia, by steam distillation; Essential oil of Melaleuca alternifolia; cas_numbers: 68647-73-4, 85085-48-9
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Developmental/reproductive toxicity

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Concern Reference
Reproductive and developmental toxicity reported in animal and in vitro tests at med-low doses.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL; ; CAS: 68647-73-4; Classification: PE; R+; D+; S; IR; Notes1: Assessment incomplete -- Scientific Literature Review for Public Comment released 4 Aug 2020

Endocrine disruption

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Concern Reference
in preliminary study, linked to prepubertal breast development in three boys, and to estrogenic and anti-androgenic activity in lab assaysHenley et al 2007 Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med. 2007 Feb 1;356(5):479-85.

Ecotoxicology

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Concern Reference
Toxic to aquatic life with long lasting effects.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Melaleuca alternifolia, ext.; -; Essential oil extract of Melaleuca alternifolia (Myrtaceae) leaf; Essential oil obtained from the leaves and terminal branchlets of Melaleuca alternifolia, by steam distillation; Essential oil of Melaleuca alternifolia; cas_numbers: 68647-73-4, 85085-48-9
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
570 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Data Sources

  • Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL; ; CAS: 68647-73-4; Classification: PE; R+; D+; S; IR; Notes1: Assessment incomplete -- Scientific Literature Review for Public Comment released 4 Aug 2020
  • European Commission, Scientific Committee on Consumer Products (SCCP) 2008. Opinion on Tea tree oil. SCCP/1155/08.
  • Pirker C et al 2003. Sensitization to tea tree oil in Germany and Austria. A multicenter study of the German Contact Dermatitis Group. J Dtsch Dermatol Ges. 2003 Aug;1(8):629-34.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Melaleuca alternifolia, ext.; -; Essential oil extract of Melaleuca alternifolia (Myrtaceae) leaf; Essential oil obtained from the leaves and terminal branchlets of Melaleuca alternifolia, by steam distillation; Essential oil of Melaleuca alternifolia; cas_numbers: 68647-73-4, 85085-48-9
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Henley et al 2007 Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med. 2007 Feb 1;356(5):479-85.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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