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MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), and Irritation (skin, eyes, or lungs) (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW_MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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shampoo100 products
conditioner84 products
facial cleanser69 products
moisturizer60 products
toothpaste56 products
facial moisturizer/treatment50 products
antiperspirant/deodorant49 products
mask47 products
toners/astringents43 products
hair treatment/serum40 products
exfoliant/scrub35 products
bar soap32 products
serums & essences32 products
recreational sunscreen31 products
body wash/cleanser29 products
foot moisturizer25 products
mouthwash24 products
foundation18 products
body oil12 products
liquid hand soap12 products
beard oil12 products
foot cleansing11 products
beard care10 products
after shave8 products
lip balm7 products
hand sanitizer7 products
body firming lotion7 products
bath oil/salts/soak6 products
after sun product6 products
diaper cream6 products
makeup primer6 products
shaving cream5 products
sunless tanning4 products
pore strips4 products
muscle/joint soreness4 products
detangler4 products
hand cream4 products
hair styling aide4 products
lip gloss4 products
setting powder/spray4 products
beard cleanser4 products
antiperspirant/deodorant (men's)3 products
makeup remover3 products
foot odor control3 products
baby soap3 products
baby sunscreen3 products
daily use with SPF3 products
shaving cream (men's)2 products
tooth whitening2 products
baby wipes2 products
fragrance for men2 products
hair-loss treatment2 products
lip balm with SPF2 products
2 products
around-eye cream1 products
nail treatment1 products
baby lotion1 products
hair spray1 products
baby shampoo1 products
fragrance for women1 products
vapor rubs1 products
tanning oil1 products
body spray1 products
hair relaxer1 products
facial powder1 products
lipstick1 products
baby toothpaste1 products
eye shadow1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancer - alters skin structure, allows other chemicals to penetrate deeper into the skin.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL; ; CAS: 68647-73-4; Classification: PE; R+; D+; S; IR; Notes1: Assessment incomplete -- Scientific Literature Review for Public Comment released 4 Aug 2020

Allergies/immunotoxicity

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Concern Reference
SCCP concludes this substance is a sensitizer in humans.European Commission, Scientific Committee on Consumer Products (SCCP) 2008. Opinion on Tea tree oil. SCCP/1155/08.
tea tree oil linked to sensitization (allergic reactions) in a number of case studiesPirker C et al 2003. Sensitization to tea tree oil in Germany and Austria. A multicenter study of the German Contact Dermatitis Group. J Dtsch Dermatol Ges. 2003 Aug;1(8):629-34.
May cause an allergic skin reaction. European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Melaleuca alternifolia, ext.; -; Essential oil extract of Melaleuca alternifolia (Myrtaceae) leaf; Essential oil obtained from the leaves and terminal branchlets of Melaleuca alternifolia, by steam distillation; Essential oil of Melaleuca alternifolia; cas_numbers: 68647-73-4, 85085-48-9

Irritation (skin, eyes, or lungs)

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Concern Reference
SCCP concludes this substance can cause skin irriration.European Commission, Scientific Committee on Consumer Products (SCCP) 2008. Opinion on Tea tree oil. SCCP/1155/08.
Eye irritation potential reported from animal and in vitro testing.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL; ; CAS: 68647-73-4; Classification: PE; R+; D+; S; IR; Notes1: Assessment incomplete -- Scientific Literature Review for Public Comment released 4 Aug 2020
Causes skin irritation.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Melaleuca alternifolia, ext.; -; Essential oil extract of Melaleuca alternifolia (Myrtaceae) leaf; Essential oil obtained from the leaves and terminal branchlets of Melaleuca alternifolia, by steam distillation; Essential oil of Melaleuca alternifolia; cas_numbers: 68647-73-4, 85085-48-9

Organ system toxicity (non-reproductive)

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Concern Reference
Acute intoxication following ingestion has been reported in humans.European Commission, Scientific Committee on Consumer Products (SCCP) 2008. Opinion on Tea tree oil. SCCP/1155/08.
May be fatal if swallowed and enters airways, is harmful if swallowed, and is harmful if inhaled.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Melaleuca alternifolia, ext.; -; Essential oil extract of Melaleuca alternifolia (Myrtaceae) leaf; Essential oil obtained from the leaves and terminal branchlets of Melaleuca alternifolia, by steam distillation; Essential oil of Melaleuca alternifolia; cas_numbers: 68647-73-4, 85085-48-9
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Developmental/reproductive toxicity

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Concern Reference
Reproductive and developmental toxicity reported in animal and in vitro tests at med-low doses.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL; ; CAS: 68647-73-4; Classification: PE; R+; D+; S; IR; Notes1: Assessment incomplete -- Scientific Literature Review for Public Comment released 4 Aug 2020

Endocrine disruption

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Concern Reference
in preliminary study, linked to prepubertal breast development in three boys, and to estrogenic and anti-androgenic activity in lab assaysHenley et al 2007 Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med. 2007 Feb 1;356(5):479-85.

Ecotoxicology

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Concern Reference
Toxic to aquatic life with long lasting effects.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Melaleuca alternifolia, ext.; -; Essential oil extract of Melaleuca alternifolia (Myrtaceae) leaf; Essential oil obtained from the leaves and terminal branchlets of Melaleuca alternifolia, by steam distillation; Essential oil of Melaleuca alternifolia; cas_numbers: 68647-73-4, 85085-48-9
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
570 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Data Sources

  • Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL; ; CAS: 68647-73-4; Classification: PE; R+; D+; S; IR; Notes1: Assessment incomplete -- Scientific Literature Review for Public Comment released 4 Aug 2020
  • European Commission, Scientific Committee on Consumer Products (SCCP) 2008. Opinion on Tea tree oil. SCCP/1155/08.
  • Pirker C et al 2003. Sensitization to tea tree oil in Germany and Austria. A multicenter study of the German Contact Dermatitis Group. J Dtsch Dermatol Ges. 2003 Aug;1(8):629-34.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Melaleuca alternifolia, ext.; -; Essential oil extract of Melaleuca alternifolia (Myrtaceae) leaf; Essential oil obtained from the leaves and terminal branchlets of Melaleuca alternifolia, by steam distillation; Essential oil of Melaleuca alternifolia; cas_numbers: 68647-73-4, 85085-48-9
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Henley et al 2007 Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med. 2007 Feb 1;356(5):479-85.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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