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KOJIC ACID

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high) and Endocrine disruption (moderate)

Cancer

Cancer concern is LOW_MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is MODERATE

Products with this Ingredient

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mask3 products
toners/astringents2 products
exfoliant/scrub1 products
bar soap1 products
facial cleanser1 products
around-eye cream1 products
shaving cream1 products

Allergies/immunotoxicity

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Concern Reference
Kojic Acid has the potential to induce skin sensitisationScientific Committee on Consumer Safety (SCCS) 2012. DRAFT OPINION ON Kojic Acid, June 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_098.pdf

Use restrictions

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Concern Reference
Not safe for use on injured or damaged skin.Scientific Committee on Consumer Safety (SCCS) 2012. DRAFT OPINION ON Kojic Acid, June 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_098.pdf
Concentration limits set for EU skin lighteners. Scientific Committee on Consumer Safety (SCCS) 2012. DRAFT OPINION ON Kojic Acid, June 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_098.pdf
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments
Concentration limit of 1% in cosmeticsBurnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA Final report of the safety assessment of Kojic acid as used in cosmetics. Int J Toxicol. 2010 Nov-Dec;29(6 Suppl):244S-73. Review.

Cancer

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Concern Reference
The European Commission's Scientific Committee on Consumer Safety reports this substance shows limited evidence of carcinogenicity.Scientific Committee on Consumer Products SCCP OPINION ON Kojic acid The SCCP adopted this opinion at its 17 th plenary of 30 September 2008
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gapsWorld Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 79;2001

Endocrine disruption

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Concern Reference
The European Commission's Scientific Committee on Consumer Safety reports this substance causes thyroid effects in animals.Scientific Committee on Consumer Products SCCP OPINION ON Kojic acid The SCCP adopted this opinion at its 17 th plenary of 30 September 2008

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
481 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • Scientific Committee on Consumer Safety (SCCS) 2012. DRAFT OPINION ON Kojic Acid, June 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_098.pdf
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA Final report of the safety assessment of Kojic acid as used in cosmetics. Int J Toxicol. 2010 Nov-Dec;29(6 Suppl):244S-73. Review.
  • Scientific Committee on Consumer Products SCCP OPINION ON Kojic acid The SCCP adopted this opinion at its 17 th plenary of 30 September 2008
  • World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 79;2001
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products intended for damaged skin due to increased risk of absorption.

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