EWG Skin Deep® | What is KETOCONAZOLE

HOW WE DETERMINE SCORES Learn more About EWG VERIFIED®

Data: Good

Ketoconazole

IMAGE SOURCE: PubChem

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Other Concerns

Use restrictions (high), Endocrine disruption (moderate), Persistence and bioaccumulation (moderate), Ecotoxicology (low), and Occupational hazards (high)

SYNONYMS

● CIS-1-ACETYL-4-[4-[[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY]PHENYL]PIP

● ERAZINE

● KETOCONAZOLE

● PIPERAZINE, 1ACETYL4[4[[(2R,4S)2(2,4DICHLOROPHENYL)2(1HIMIDAZOL1YLMETHYL)1,3DIOXOLAN4YL]METHOXY]PHENYL], REL

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient

Ketoconazole is a heterocyclic compound.

Common concerns

See how this product scores for common concerns.

LOW

Cancer
LOW

Allergies & Immunotoxicity
MODERATE

Developmental and Reproductive Toxicity
HIGH

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

styling gel/lotion

1 products

Use restrictions

CONCERN	REFERENCE
Violation of government restrictions - Banned or found unsafe for use in cosmetics	CosIng

Occupational hazards

CONCERN	REFERENCE
Allowed workplace exposures restricted to low doses	Open scientific literature

Endocrine disruption

CONCERN	REFERENCE
Human endocrine disruptor - strong evidence	European Commission on Endocrine Disruption
Limited evidence of endocrine disruption	Scorecard.org Toxicity Information
endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox study	Our Stolen Future Endocrine Disruptors

Persistence and bioaccumulation

CONCERN	REFERENCE
Persistent or bioaccumulative and moderate to high toxicity concern in humans	Open scientific literature
Not suspected to be bioaccumulative	Environment Canada Domestic Substance List

Developmental/reproductive toxicity

CONCERN	REFERENCE
Limited evidence of reproductive toxicity	CPS&Q - Classification & Labelling

Ecotoxicology

CONCERN	REFERENCE
Wildlife and environmental toxicity	CPS&Q - Classification & Labelling
Not suspected to be an environmental toxin	Environment Canada Domestic Substance List

Data gaps

CONCERN	REFERENCE
28566 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Classified as not expected to be potentially toxic or harmful	Environment Canada Domestic Substance List

European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Open scientific/peer reviewed literature
EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
Colborn T, D Dumanoski, JP Myers. 2006. Widespread Pollutants with Endocrine-disrupting Effects. Updated from original listing in "Our Stolen Future" (1996).
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED^® mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST

Low Availability

Moderate Availability

High Availability