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IODOPROPYNYL BUTYLCARBAMATE
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high) and Non-reproductive organ system toxicity (low)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| eye shadow | 7 products |
| exfoliant/scrub | 6 products |
| body wash/cleanser | 4 products |
| hair styling aide | 3 products |
| makeup remover | 2 products |
| body firming lotion | 2 products |
| eye liner | 2 products |
| hair treatment/serum | 2 products |
| concealer | 2 products |
| styling gel/lotion | 1 products |
| moisturizer | 1 products |
| conditioner | 1 products |
| hair spray | 1 products |
| baby wipes | 1 products |
| moisturizer with SPF | 1 products |
| eye makeup remover | 1 products |
| bar soap | 1 products |
Use restrictions
| Concern | Reference |
|---|---|
| Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use in products intended to be aerosolized, according to industry safety panel (Cosmetic Ingredient Review, CIR) | Cosmetic Ingredient Review Assessments |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit) | Japan's Standards for Cosmetics |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Cosmetic Ingredient Review Assessments |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Human any toxicant or allergen - strong evidence | Cosmetic Ingredient Review Assessments |
| Study demonstrates allergic contact dermatitis of chemical in cosmetic cream | Pazzaglia M, Tosti A 1999. Allergic contact dermatitis from 3-iodo-2-propynyl-butylcarbamate in a cosmetic cream. Contact Dermatitis. 1999 Nov;41(5):290. |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Limited evidence of gastrointestinal or liver toxicity | US EPA Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788 (Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under Chemical Expansion. http://www.epa.gov/tri/chemical/hazard_cx.htm |
| One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) | EPA Toxic Release Inventory PBTs |
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Ecotoxicology
| Concern | Reference |
|---|---|
| Suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern | Reference |
|---|---|
| Safety assessment was based on related chemical | Cosmetic Ingredient Review Assessments |
| 50 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Not safe for use in products intended to be aerosolized, according to industry safety panel (Cosmetic Ingredient Review, CIR) | Cosmetic Ingredient Review Assessments |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
- Pazzaglia M, Tosti A 1999. Allergic contact dermatitis from 3-iodo-2-propynyl-butylcarbamate in a cosmetic cream. Contact Dermatitis. 1999 Nov;41(5):290.
- US EPA Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788 (Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under Chemical Expansion. http://www.epa.gov/tri/chemical/hazard_cx.htm
- EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
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