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HOMOSALATE
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Enhanced skin absorption, Use restrictions (moderate), Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Contamination concerns (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| beach & sport sunscreen | 356 products |
| moisturizer with SPF | 105 products |
| lip balm with SPF | 13 products |
| baby sunscreen | 11 products |
| body spray | 9 products |
| fragrance for women | 8 products |
| bronzer/highlighter | 6 products |
| BB cream | 5 products |
| makeup with SPF | 2 products |
| other eye makeup | 1 products |
| facial moisturizer/treatment | 1 products |
| hair treatment/serum | 1 products |
| makeup primer | 1 products |
Contamination concerns
| Chemical |
|---|
| SALICYLIC ACID |
| TRIMETHYLCYCLOHEXANOL |
Enhanced skin absorption
| Concern | Reference |
|---|---|
| Homosalate increased absorption of 2,4D (a pesticide) by 32.1% and decreased the lag time by 60%. | Pont AR, Charron AR, Brand RM 2004. Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. Toxicol Appl Pharmacol 195(3): 348-354. |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit) | Japan's Standards for Cosmetics |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as expected to be toxic or harmful | Environment Canada Domestic Substance List |
Endocrine disruption
| Concern | Reference |
|---|---|
| Reduced DHT-induced AR activation in MDA-kb2 cells in a concentration-dependent manner, acted as estrogen agonists on MCF cells | {Ma 2003} |
Ecotoxicology
| Concern | Reference |
|---|---|
| Suspected to be an environmental toxin and be persistent or bioaccumulative | Environment Canada Domestic Substance List |
| Suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern | Reference |
|---|---|
| 726 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
Data Sources
- Pont AR, Charron AR, Brand RM 2004. Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. Toxicol Appl Pharmacol 195(3): 348-354.
- Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- {Ma 2003}
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- Products with the EWG VERIFIED mark have met the program’s impurity and use restrictions based on EWG's review of the company's data.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
ABOUT EWG VERIFIED™
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer
