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GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Neurotoxicity (low), Endocrine disruption (moderate), Non-reproductive organ system toxicity (moderate), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW_MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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facial moisturizer/treatment117 products
foundation86 products
mask71 products
serums & essences60 products
concealer35 products
facial cleanser34 products
moisturizer29 products
moisturizer with SPF29 products
lipstick28 products
around-eye cream23 products
toners/astringents15 products
beach & sport sunscreen14 products
shampoo14 products
exfoliant/scrub11 products
hair treatment/serum10 products
lip balm10 products
hand cream9 products
BB cream7 products
anti-aging7 products
makeup remover7 products
baby wipes6 products
body wash/cleanser6 products
bronzer/highlighter6 products
makeup primer6 products
baby lotion5 products
eye shadow4 products
conditioner4 products
baby soap4 products
blush4 products
oil controller3 products
shaving cream3 products
baby shampoo3 products
facial powder3 products
hair styling aide3 products
makeup with SPF2 products
liquid hand soap2 products
baby sunscreen2 products
toothpaste2 products
antiperspirant/deodorant (men's)1 products
hair spray1 products
other eye makeup1 products
body spray1 products
styling gel/lotion1 products
bar soap1 products
CC cream1 products
eye makeup remover1 products
antiperspirant/deodorant1 products
1 products
skin fading/lightener1 products
shaving cream (men's)1 products
mouthwash1 products
body firming lotion1 products
after shave1 products

Endocrine disruption

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Concern Reference
Licorice and its derivative substances disrupt function of the adrenal (corticosteroid hormone) axis.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Anti-androgenic effects of licorice have been observed in humans.Paul Grant & Shamin Ramasamy 2012. An update on plant derived anti-androgens. International journal of endocrinology and metabolism 10(2), 497-502.
Licorice extract exhibits estrogenic activity in vitro.D T. Zava, M. Blen & G. Duwe. 1997. Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture. Environmental health perspectives 105 Suppl 3, 637-45.
Licorice extracts impacted pituitary hormone secretion in vitro and in vivo in rats.Ho Young Lee, Dae Young Jung, Hyekyung Ha, Sam Sik Kang, Ju Sun Kim & Chungsook Kim 2007. Induction of growth hormone release by glycyrrhizae radix on rat. Journal of biochemistry and molecular biology 40(6), 979-85.

Developmental/reproductive toxicity

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Concern Reference
Licorice consumption during pregnancy is linked to adverse birth outcomes.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Licorice extract affected male reprodutive function in rats.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.

Organ system toxicity (non-reproductive)

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Concern Reference
Licorice and its constituents/derivatives affect the cardiovascular system by disrupting hormones involved in water/salt balance.Mikkel R Deutch, Daniela Grimm, Markus Wehland, Manfred Infanger & Marcus Krüger. 2019. Bioactive Candy: Effects of Licorice on the Cardiovascular System. Foods (Basel, Switzerland) 8(10).
Effects on liver enzyme function have been observed in humans and animals.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Chronic exposure to licorice extract caused liver damage in fish.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.

Allergies/immunotoxicity

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Concern Reference
Licorice and its constituents/derivatives can impact immune function.Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.

Irritation (skin, eyes, or lungs)

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Concern Reference
Mixed evience of minor skin irritation in humans. No evidence of skin irritation in animal testing.Cosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-2018; Chemical_Name: GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT; ; ; Classification: QQQ01,QQQ11;

Neurotoxicity

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Concern Reference
Licorice derivatives have exhibited neuroprotective, sedative, and antidepressant effects in various studies, indicating a capacity to elicit nervous system effects.Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
514 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
  • Paul Grant & Shamin Ramasamy 2012. An update on plant derived anti-androgens. International journal of endocrinology and metabolism 10(2), 497-502.
  • D T. Zava, M. Blen & G. Duwe. 1997. Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture. Environmental health perspectives 105 Suppl 3, 637-45.
  • Ho Young Lee, Dae Young Jung, Hyekyung Ha, Sam Sik Kang, Ju Sun Kim & Chungsook Kim 2007. Induction of growth hormone release by glycyrrhizae radix on rat. Journal of biochemistry and molecular biology 40(6), 979-85.
  • Mikkel R Deutch, Daniela Grimm, Markus Wehland, Manfred Infanger & Marcus Krüger. 2019. Bioactive Candy: Effects of Licorice on the Cardiovascular System. Foods (Basel, Switzerland) 8(10).
  • Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.
  • Cosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-2018; Chemical_Name: GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT; ; ; Classification: QQQ01,QQQ11;
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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