Menu Close Menu

Menu

GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Neurotoxicity (low), Endocrine disruption (moderate), Non-reproductive organ system toxicity (moderate), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW_MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

Expand content Collapse content
facial moisturizer/treatment150 products
serums & essences90 products
foundation86 products
mask82 products
facial cleanser41 products
daily use with SPF37 products
concealer35 products
moisturizer34 products
around-eye cream33 products
lipstick28 products
toners/astringents23 products
shampoo18 products
baby wipes17 products
exfoliant/scrub17 products
recreational sunscreen16 products
anti-aging10 products
BB cream10 products
antiperspirant/deodorant9 products
makeup primer9 products
makeup remover9 products
hand cream8 products
lip balm8 products
hair treatment/serum8 products
body wash/cleanser7 products
bronzer/highlighter5 products
eye shadow4 products
blush4 products
setting powder/spray4 products
baby lotion3 products
hair styling aide3 products
shaving cream3 products
after shave3 products
conditioner3 products
body firming lotion3 products
oil controller3 products
baby sunscreen2 products
bar soap2 products
liquid hand soap2 products
facial powder2 products
toothpaste2 products
shaving cream (men's)2 products
lip balm with SPF1 products
depilatory1 products
antiperspirant/deodorant (men's)1 products
skin fading/lightener1 products
beard cleanser1 products
1 products
mouthwash1 products
hair spray1 products
baby soap1 products
baby shampoo1 products
other eye makeup1 products
styling gel/lotion1 products
CC cream1 products

Endocrine disruption

Expand content Collapse content
Concern Reference
Licorice and its derivative substances disrupt function of the adrenal (corticosteroid hormone) axis.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Anti-androgenic effects of licorice have been observed in humans.Paul Grant & Shamin Ramasamy 2012. An update on plant derived anti-androgens. International journal of endocrinology and metabolism 10(2), 497-502.
Licorice extract exhibits estrogenic activity in vitro.D T. Zava, M. Blen & G. Duwe. 1997. Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture. Environmental health perspectives 105 Suppl 3, 637-45.
Licorice extracts impacted pituitary hormone secretion in vitro and in vivo in rats.Ho Young Lee, Dae Young Jung, Hyekyung Ha, Sam Sik Kang, Ju Sun Kim & Chungsook Kim 2007. Induction of growth hormone release by glycyrrhizae radix on rat. Journal of biochemistry and molecular biology 40(6), 979-85.

Developmental/reproductive toxicity

Expand content Collapse content
Concern Reference
Licorice consumption during pregnancy is linked to adverse birth outcomes.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Licorice extract affected male reprodutive function in rats.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.

Organ system toxicity (non-reproductive)

Expand content Collapse content
Concern Reference
Licorice and its constituents/derivatives affect the cardiovascular system by disrupting hormones involved in water/salt balance.Mikkel R Deutch, Daniela Grimm, Markus Wehland, Manfred Infanger & Marcus Krüger. 2019. Bioactive Candy: Effects of Licorice on the Cardiovascular System. Foods (Basel, Switzerland) 8(10).
Effects on liver enzyme function have been observed in humans and animals.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
Chronic exposure to licorice extract caused liver damage in fish.Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.

Allergies/immunotoxicity

Expand content Collapse content
Concern Reference
Licorice and its constituents/derivatives can impact immune function.Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.

Irritation (skin, eyes, or lungs)

Expand content Collapse content
Concern Reference
Mixed evience of minor skin irritation in humans. No evidence of skin irritation in animal testing.Cosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-2018; Chemical_Name: GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT; ; ; Classification: QQQ01,QQQ11;

Neurotoxicity

Expand content Collapse content
Concern Reference
Licorice derivatives have exhibited neuroprotective, sedative, and antidepressant effects in various studies, indicating a capacity to elicit nervous system effects.Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.

Data gaps

Expand content Collapse content
Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
514 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

Expand content Collapse content
Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • Somayeh Nazari, Maryam Rameshrad & Hossein zadeh 2017. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research : PTR 31(11), 1635-1650.
  • Paul Grant & Shamin Ramasamy 2012. An update on plant derived anti-androgens. International journal of endocrinology and metabolism 10(2), 497-502.
  • D T. Zava, M. Blen & G. Duwe. 1997. Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture. Environmental health perspectives 105 Suppl 3, 637-45.
  • Ho Young Lee, Dae Young Jung, Hyekyung Ha, Sam Sik Kang, Ju Sun Kim & Chungsook Kim 2007. Induction of growth hormone release by glycyrrhizae radix on rat. Journal of biochemistry and molecular biology 40(6), 979-85.
  • Mikkel R Deutch, Daniela Grimm, Markus Wehland, Manfred Infanger & Marcus Krüger. 2019. Bioactive Candy: Effects of Licorice on the Cardiovascular System. Foods (Basel, Switzerland) 8(10).
  • Giulia Pastorino, Laura Cornara, Sónia Soares, Francisca Rodrigues & M Beatriz P. P. Oliveira. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research : PTR 32(12), 2323-2339.
  • Cosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-2018; Chemical_Name: GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT; ; ; Classification: QQQ01,QQQ11;
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer